中国医药科学2025，Vol.15Issue(1)：23-26,4.DOI:10.20116/j.issn2095-0616.2025.01.06
锌在孤独症谱系障碍中调控谷氨酸能受体的研究新进展
Recent advances in zinc regulation of glutamatergic receptors in autism spectrum disorders
摘要
Abstract
Autism spectrum disorder(ASD)is a neurodevelopmental disorder characterized by deficits in social communication and repetitive behaviors and interests,with a complex pathogenesis including neuroinflammation,metabolic disturbance of zinc and abnormal neurotransmission.Prenatal zinc deficiency can increase the incidence of ASD in the offspring.On the contrary,prenatal zinc supplementation can significantly reduce the incidence of ASD in the offspring.Glutamate is a major mediator of excitatory synaptic transmission.Abnormal glutamatergic neurotransmission can exacerbate pathological changes in ASD.This process primarily involves ionotropic glutamate receptors,on which the dynamic balance of zinc-regulated excitatory and inhibitory synaptic neurotransmission also depends.However,the role and potential mechanisms of zinc in post-ASD glutamatergic neurotransmission remain to be explored.In this paper,the physiological function of zinc,glutaminergic synaptic signal transduction,and the potential mechanism of zinc regulation of glutaminergic receptors after ASD were reviewed in order to explore the potential molecular targets of zinc therapy in patients with ASD.关键词
锌/孤独症谱系障碍/谷氨酸能突触/谷氨酸能受体/信号转导Key words
Zinc/Autism spectrum disorder/Glutamatergic synapses/Glutamatergic receptors/Signaling分类
医药卫生引用本文复制引用
胡利敏,杨嘉涵,朱月,陈艳,高原,李丽丽..锌在孤独症谱系障碍中调控谷氨酸能受体的研究新进展[J].中国医药科学,2025,15(1):23-26,4.基金项目
国家自然科学基金(82101972 （）
82001382) （）
江苏省苏州市姑苏卫生人才计划人才科研项目(GSWS2021030). （GSWS2021030）
