中国医药科学2025，Vol.15Issue(1)：128-131,173,5.DOI:10.20116/j.issn2095-0616.2025.01.31
氯醋甲胆碱支气管激发试验在儿童支气管高反应性评估中实用性和安全性研究
Research on the practicability and safety of methylcholine chloride bronchial provocation test in the evaluation of bronchial hyperresponsiveness in children
摘要
Abstract
Objective To investigate the practicability and safety of methacholine chloride(MCT)bronchial provocation test in the evaluation of bronchial hyperresponsiveness in children.Methods A total of 80 children with bronchial asthma aged 5-14 years admitted to and treated in the Peoples Hospital of Liupanshui City from April 2023 to February 2024 were selected,and all the subjects in the research were treated with pulmonary function examination and MCT provocation test,and the children with bronchial asthma were randomly divided into the pulmonary function group and the MCT group.All the children received systematic treatment.The children in the pulmonary function group were guided by pulmonary function examination and exhaled nitric oxide to adjust the dose of glucocorticoid,while the children in the MCT group were guided by basic pulmonary function examination and MCT provocation test to adjust the dose of glucocorticoid.After the treatment,the differences of pulmonary function indices,changes of pulmonary function and airway inflammation level indices were compared between the two groups.Results The indices of peak expiratory flow variability,the percentage of forced expiratory volume in the first second to the predicted value and forced vital capacity in the MCT group were all higher than those in the pulmonary function test group.The peak expiratory flow rate,mid-expiratory flow rate of 25%,50%and 75%,fractional exhaled nitric oxide and concentration of alveolar and alveolar region exhaled nitric oxide indices were all higher than those of pulmonary function examination group,with statistically significant differences(P＜0.05).Conclusion MCT bronchial provocation test is very practical and safe in the evaluation of bronchial hyperresponsiveness in children,and it has important value and application prospect.关键词
氯醋甲胆碱支气管激发试验/儿童支气管高反应性评估/哮喘/临床效果Key words
Methylcholine chloride bronchial provocation test/Evaluation of bronchial hyperresponsiveness in children/Asthma/Clinical efficacy分类
临床医学引用本文复制引用
宾婧,刘宽,熊强..氯醋甲胆碱支气管激发试验在儿童支气管高反应性评估中实用性和安全性研究[J].中国医药科学,2025,15(1):128-131,173,5.基金项目
贵州省六盘水市科技计划项目(52020-2023-0-1-64). （52020-2023-0-1-64）
