中国医药科学2025，Vol.15Issue(1)：145-148,4.DOI:10.20116/j.issn2095-0616.2025.01.35
血栓弹力图在妊娠高血压疾病评估中的应用价值
Application value of thromboelastography in evaluation of hypertensive disorders of pregnancy
摘要
Abstract
Objective To investigate the value of thromboelastography(TEG)in the evaluation of hypertensive disorders of pregnancy(HDP).Methods HDP pregnant women who underwent pregnancy check-up or were waiting for delivery in Longyan People Hospital of Fujian from September 2021 to September 2022 were selected as the research object,and they were divided into the observation group(n=27).Meanwhile,healthy pregnant women who underwent pregnancy check-up or were waiting for delivery in Longyan People Hospital of Fujian during the same period were selected and divided into the control group(n=63).4 indices of coagulation and TEG were collected from the two groups.The TEG indices of the control group were compared with the normal reference range given by the manufacturer.The clinical data of the two groups were observed and compared.The correlations between TEG indices and conventional 4 indices of coagulation were analyzed to assess the evaluation value of TEG indices for HDP.Results The TEG-related indices and 95%confidence interval of the control group were within the reference value range of the normal population.The levels of prothrombin time(PT),activated partial thromboplastin time(APTT)and fibrinogen(FIB)in the observation group were lower than those in the control group,while the thrombin time(TT)was higher than that in the control group,with statistically significant differences(all P＜0.05).The reaction time(R)and coagulation time(K)in the observation group were lower than those in the control group,while the coagulation angle(α angle)and the maximum amplitude(MA)of thrombus were higher than those in the control group,with statistically significant differences(all P＜0.05).R was positively correlated with PT(r=0.287,P=0.031)and APTT(r=0.342,P=0.009).The α angle was positively correlated with FIB(r=0.701,P=0.004).There was a negative correlation between K and FIB(r=-0.468,P=0.001).The areas under the curve(AUC)of conventional 4 indices of coagulation were smaller than those of TEG indices,and MA(AUC=0.814,P＜0.01)had the highest evaluation efficiency in TEG indices.Conclusion Compared with the 4 indices of conventional coagulation,TEG indices have more advantages in evaluating HDP,in which MA has the highest evaluation value,so it is recommended to use TEG indices in evaluating the clinical condition of HDP.关键词
妊娠期/高血压/血栓弹力图/诊断价值Key words
Pregnancy/Hypertension/Thromboelastogram/Diagnostic value分类
医药卫生引用本文复制引用
陈宏飞,沈肖明,魏权..血栓弹力图在妊娠高血压疾病评估中的应用价值[J].中国医药科学,2025,15(1):145-148,4.基金项目
福建省龙岩市新罗区科技项目(2020XL18-11). （2020XL18-11）
