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EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis

Yang Chen Haibo Si Shanshan Dong Xin Zeng Qing Xu Mingwei Liang Guangneng Liao Lan Li Bin Shen Yanrong Lu

中华医学杂志（英文版）2025，Vol.138Issue(1)：79-92,14.

中华医学杂志（英文版）2025，Vol.138Issue(1)：79-92,14.DOI:10.1097/CM9.0000000000003186

EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis

Yang Chen ¹Haibo Si ¹Shanshan Dong ²Xin Zeng ¹Qing Xu ³Mingwei Liang ¹Guangneng Liao ⁴Lan Li ¹Bin Shen ¹Yanrong Lu¹

作者信息

1. Department of Orthopedic Surgery&Key Laboratory of Transplant Engineering and Immunology,Regenerative Medicine Research Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China
2. Department of Discipline Construction,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China
3. Institute of Clinical Pathology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China
4. Experimental Animal Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China
折叠

摘要

关键词

Osteoarthritis/EZH2/MicroRNA-142-3p/HMGB1/Endoplasmic reticulum stress/Pyroptosis

Key words

Osteoarthritis/EZH2/MicroRNA-142-3p/HMGB1/Endoplasmic reticulum stress/Pyroptosis

引用本文复制引用

Yang Chen,Haibo Si,Shanshan Dong,Xin Zeng,Qing Xu,Mingwei Liang,Guangneng Liao,Lan Li,Bin Shen,Yanrong Lu..EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis[J].中华医学杂志（英文版）,2025,138(1):79-92,14.

基金项目

This work was supported by the National Natural Science Foundation of China(No.81802210),the Science&Technology Department of Sichuan Province(No.2021YFS0122),the Health Commission of Sichuan Province(No.20PJ056),and the National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University(No.Z2018B20). （No.81802210）

中华医学杂志（英文版）

ISSN：0366-6999

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