关注环境温度对骨代谢的影响OA北大核心CSTPCD

Exposure to low temperatures significantly increases the risk of fractures and negatively impacts bone quality,possibly through pathways involving energy distribution,neuropeptide Y regulation,and plasma exosome activity,leading to bone loss.Conversely,high-temperature environments may offer protective benefits by safeguarding bone quality and improving bone microstructure,which is associated with a reduced risk of fractures.Additionally,temperature can di-rectly regulate the growth and metabolism of chondrocytes,thereby influencing bone growth.This article analyzes the dual effects of environmental temperature on bone metabolism from both basic research and epidemiological perspectives,provi-ding insights into disease prevention and proposing temperature modulation as a potential treatment approach.The research suggests new strategies for clinical management of osteoporosis and bone health,particularly in the context of extreme tem-peratures that are increasingly prevalent in modern climates,indicating that appropriate adjustment of temperature exposure may emerge as a novel method for preventing and treating bone diseases.