中华骨质疏松和骨矿盐疾病杂志2024，Vol.17Issue(6)：611-622,12.DOI:10.3969/j.issn.1674-2591.2024.06.010
骨质疏松症相关基因研究进展
Research progress of osteoporosis related genes
摘要
Abstract
Osteoporosis is a bone degenerative disease with aging,which is characterized by decreased bone for-mation and increased bone resorption,often accompanied by fracture.In recent years,great progress has been made in the study of osteoporosis-related genes.Calcitonin gene-related peptide(CGRP),microRNA(microRNA)have been found in delaying the progression of osteoporosis.In addition,receptor activator of nuclear factor-κB ligand(RANKL),forkhead protein F1(Foxf1),and fat mass and obesity-associated protein(FTO)have also been found to promote the development of osteoporosis.This article summarizes the mechanism of promoting osteoporosis and inhibiting osteoporosis related genes in the pathological process of osteoporosis,in order to provide some reference for the clinical treatment of osteoporosis.关键词
骨质疏松症/降钙素基因相关肽/核因子κB受体活化因子配体/微小RNAKey words
osteoporosis/genes/calcitonin gene-related peptide(CGRP)/receptor activator of nuclear factor-κB ligand(RANKL)/microRNA(miRNA)分类
医药卫生引用本文复制引用
朱丽娴,王艳华,余鑫..骨质疏松症相关基因研究进展[J].中华骨质疏松和骨矿盐疾病杂志,2024,17(6):611-622,12.基金项目
2023年度肿瘤微环境与免疫治疗湖北省重点实验室(三峡大学)开放基金课题(2023KZL03) （三峡大学）
