中华骨质疏松和骨矿盐疾病杂志2024，Vol.17Issue(6)：631-637,7.DOI:10.3969/j.issn.1674-2591.2024.06.012
Sirtuins在骨质疏松症中的研究进展
Research progress of Sirtuins in osteoporosis
摘要
Abstract
Sirtuins 1-7(SIRT1-SIRT7)are a family of nicotinamide adenine dinucleotide-dependent deacetylases that have the ability to promote longevity and fight age-related diseases.Sirtuins play a key role in normal bone development and homeostasis through their direct action on bone cells,and their disorder may lead to an imbalance in bone homeostasis leading to osteoporosis.SIRT1 regulates osteoclast activity,osteogenic differentiation of mesenchymal stem cells,and bone mineralization,and maintains bone homeostasis in bone formation and bone resorption by regulating mitochondrial homeostasis.SIRT3 can regulate mitochondrial function to regulate osteoblast differentiation and mesenchymal stem cell aging.SIRT6 can induce osteoclast apoptosis,promote osteoblast activity and maintain mitochon-drial homeostasis to improve mesenchymal stem cell aging and osteogenic differentiation.SIRT7 also plays an important role in regulating mesenchymal stem cell osteogenic differentiation.Therefore,Sirtuins may be potential targets for regula-ting bone remodeling and treating osteoporosis.关键词
Sirtuins/骨质疏松症/骨重塑Key words
Sirtuins/osteoporosis/bone remodeling分类
医药卫生引用本文复制引用
吴火峰,张亮,李争光,宰爽嘉,孙华,张永博,陈浏阳,戴睿..Sirtuins在骨质疏松症中的研究进展[J].中华骨质疏松和骨矿盐疾病杂志,2024,17(6):631-637,7.基金项目
国家自然科学基金面上项目(82172462) （82172462）
江苏省中医药科技发展计划项目(YB2020085) （YB2020085）
江苏省苏北人民医院院级科研基金(交叉合作专项)(SBJC21014) （交叉合作专项）
江苏省第六期"333工程"优秀青年人才科研项目(苏人才办[2022]21号) （苏人才办[2022]21号）
扬州市重点研发项目(社会发展)(YZ2021083) （社会发展）
