中山大学学报（医学科学版）2025，Vol.46Issue(1)：1-10,10.
单细胞测序在缺血再灌注领域的研究进展
Research Progress in Single-cell Sequencing for Ischemia-reperfusion Injury
摘要
Abstract
Ischemia reperfusion injury(IRI)is often accompanied by serious clinical manifestations,including myocardial hibernation,acute heart failure,brain dysfunction,kidney dysfunction,gastrointestinal dysfunction,liver transplant rejection,systemic inflammatory response syndrome,multiple organ dysfunction syndrome,and so on,which pose important treatment challenges for doctors in clinical practice.Single cell sequencing technology is high-throughput sequencing of the genome,transcriptome,or epigenome at the single-cell level,in order to reveal cellular heterogeneity,and to understand the developmental trajectory,type,state,and various interactions of cells.Since its first discovery,single-cell sequencing technology has been widely applied in various fields,especially in early diagnosis and personalized treatment of tumors.This article mainly reviews the application and progress of single-cell sequencing in various organ dysfunctions caused by IRI,so as to further understand the mechanisms and signaling pathways of IRI,and to provide new ideas for targeted therapy of organ IRI.关键词
缺血再灌注损伤/单细胞测序/凋亡/移植/异质性/信号通路Key words
ischemia reperfusion injury/single cell sequencing/apoptosis/transplantation/heterogeneity/signal pathway引用本文复制引用
张洁,杨正飞..单细胞测序在缺血再灌注领域的研究进展[J].中山大学学报（医学科学版）,2025,46(1):1-10,10.基金项目
国家自然科学基金(8237081291) （8237081291）
