中山大学学报（医学科学版）2025，Vol.46Issue(1)：147-153,7.
血浆纤维蛋白原与定量CT定义的骨质疏松症的相关性分析
Analysis of the Correlation between Plasma Fibrinogen and Osteoporosis Defined by Quantitative Computed Tomography
摘要
Abstract
[Objective]To clarify the associations between plasma fibrinogen(Fbg)and volumetric bone mineral density(vBMD)as well as osteoporosis measured by quantitative computed tomography(QCT),and to explore the role of plasma Fbg in early screening and diagnosis of osteoporosis.[Methods]Patients with hypertension who were hospitalized in the Department of Endocrinology of Sun Yat-sen Memorial Hospital of Sun Yat-sen University from January 2018 to June 2022 and underwent QCT examinations were included for cross-sectional analysis.The study analyzed the correlation between plasma Fbg and osteoporosis in patients.The diagnostic efficacy of plasma Fbg for osteoporosis was evaluated by the area under the receiver operating characteristic(ROC)curve(AUC).[Results]Totally 441 subjects were included in the analysis,with an average age of 46.0±14.5 years and a prevalence of osteoporosis of 6.4%(28/441).As the level of plasma fibrinogen increased,the incidence of osteoporosis significantly increased(P<0.000 1)while the average bone mineral density of L1 and L2 were significantly decreased(P<0.05).Compared with the first quartile of plasma Fbg(1.99g/L-2.37g/L),the risk of osteoporosis in the fourth quartile of plasma Fbg(3.67g/L-4.46g/L)increased by 8.85 times after adjusting for related confounding factors.[Conclusion]This study found a negative correlation between plasma fibrinogen levels and bone density in patients with hypertension.Plasma fibrinogen levels may serve as a potential screening indicator for osteoporosis,aiding in early diagnosis and therapeutic monitoring.This discovery offers a new perspective for the study of bone metabolic diseases and warrants further investigation.关键词
骨质疏松症/高血压/纤维蛋白原/定量CT/体积骨密度Key words
osteoporosis/hypertension/fibrinogen/quantitative computed tomography/volumetric bone mineral density分类
医药卫生引用本文复制引用
陈映娜,孙侃,李娜,王成芷,黄楚霖,李玲玲,肖辉盛,劳国娟..血浆纤维蛋白原与定量CT定义的骨质疏松症的相关性分析[J].中山大学学报（医学科学版）,2025,46(1):147-153,7.基金项目
广东基础与应用基础研究基金(2020A1515110963) （2020A1515110963）
