中山大学学报（医学科学版）2025，Vol.46Issue(1)：154-160,7.
双重膜滤过式血浆置换治疗伴呼吸衰竭的视神经脊髓炎谱系疾病的疗效评价
Efficacy Evaluation of Initial Double Filtration Plasmapheresis in NMOSD with Respiratory Insufficiency
摘要
Abstract
[Objective]To discuss the clinical manifestations and image features of Neuromyelitis Optica Spectrum Disorder(NMOSD)with respiratory insufficiency.We present a retrospective review about the use of double filtration plasmapheresis in the treatment of the acute attack of NMOSD in these patients.[Methods]All of our patients with central respiratory insufficiency who suffered attacks of NMOSD were retrospectively considered for inclusion.Extended Disability Status Scale(EDSS)scores were compared within six months after double membrane filtration plasma exchange.[Results]The clinical data of the six patients included were analyzed.Magnetic Resonance Imaging confirmed that the demyelinating plaques in our patients could involve the medulla oblongata and upper spinal cord.They were managed by plasma exchange given as an initial therapy.The clinical symptoms improved significantly and the patients were successfully withdrawn from the ventilator,with EDSS scores significantly reduced(P<0.001).[Conclusion]Demyelination of medulla oblongata and upper spinal cord in NMOSD may lead to acute life-threatening respiratory compromise,and early initiation of double filtration plasmapheresis can be a safe and effective treatment.关键词
视神经脊髓炎谱系疾病/呼吸衰竭/双重膜滤过式血浆置换/延髓/高颈段脊髓Key words
neuromyelitis optica spectrum disorder/respiratory insufficiency/double filtration plasmapheresis/medulla oblongata/upper spinal cord分类
医药卫生引用本文复制引用
张赛,陈希,曾涛..双重膜滤过式血浆置换治疗伴呼吸衰竭的视神经脊髓炎谱系疾病的疗效评价[J].中山大学学报（医学科学版）,2025,46(1):154-160,7.基金项目
广州市卫生健康科技项目(20231A011016) （20231A011016）
