中医药信息2025，Vol.42Issue(2)：11-16,6.DOI:10.19656/j.cnki.1002-2406.20250202
温中消痞汤对脾胃虚寒型功能性消化不良大鼠胃肠动力及胃肠激素MTL、GAS、VIP的影响
Effects of Wenzhong Xiaopi Decoction on Gastrointestinal Motility and Gastrointestinal Hormones MTL,GAS,and VIP in Rats with Functional Dyspepsia of Spleen-Stomach Deficiency and Cold Syndrome
摘要
Abstract
Objective:To observe the effects of Wenzhong Xiaopi Decoction on gastrointestinal motility and serum levels of motilin(MTL),gastrin(GAS),and vasoactive intestinal peptide(VIP)in rats with functional dyspepsia of spleen-stomach deficiency and cold syndrome,and to explore the mechanism of its therapeutic action for this syndrome.Methods:Seventy 6-day-old SPF female rats were randomly divided into a blank control group(15 rats),model control group(15 rats),mosapride group(10 rats),and Wenzhong Xiaopi Decoction high-,medium-,and low-dose groups(10 rats each).Except for the blank control group,all other groups were modeled for functional dyspepsia of spleen-stomach deficiency and cold syndrome by administering 1%iodoacetamide combined with 2%sucrose,followed by cold(4℃)vinegar gavage.The blank control and model control groups received saline gavage,while the Wenzhong Xiaopi Decoction low-,medium-,and high-dose groups and the mosapride group received Wenzhong Xiaopi Decoction(7.1,14.2,28.4 g/kg)and mosapride(1.575 mg/kg)gavage,respectively,for 30 consecutive days.Gastric emptying rate and small intestine transit rate were measured,gastric tissue pathology was observed via HE staining,and serum MTL,GAS,and VIP levels were measured using ELISA.Results:Compared with the model control group,all drug intervention groups showed significant improvement in mental state,activity levels,stool quality,food intake,and body weight;gastric emptying rate significantly increased(P<0.01);serum MTL and GAS levels increased(P<0.01,P<0.05),while VIP levels in serum decreased(P<0.01),particularly in the mosapride and high-dose Wenzhong Xiaopi Decoction groups(P<0.01,P<0.05).Conclusion:Wenzhong Xiaopi Decoction improves gastrointestinal motility by increasing gastric emptying rate and small intestine transit rate,promoting MTL and GAS expression,and inhibiting VIP expression in rats with functional dyspepsia of spleen-stomach deficiency and cold syndrome,thus showing therapeutic effects on functional dyspepsia.关键词
温中消痞汤/脾胃虚寒/功能性消化不良/胃肠激素Key words
Wenzhong Xiaopi Decoction/Spleen-stomach deficiency and cold syndrome/Functional dyspepsia/Gastrointestinal hormone引用本文复制引用
赵琦,李开楊,周蓉,杨月月,石慧,杨梅,黄敬,郭伟鑫..温中消痞汤对脾胃虚寒型功能性消化不良大鼠胃肠动力及胃肠激素MTL、GAS、VIP的影响[J].中医药信息,2025,42(2):11-16,6.基金项目
贵州省教育厅2023年度自然科学研究项目(黔教技[2023]017) （黔教技[2023]017）
中医药管理局中医药、民族医药科学技术课题研究项目(QZYY-2023-015) （QZYY-2023-015）
