摘要
Abstract
Objective:To investigate the effects of Modified Huanglian Jiedu Decoction(MHJD)on wound healing in patients with damp-heat downward syndrome after low fistula-in-ano surgery and to analyze its mechanism from the perspectives of anti-inflammation,immune modulation,and nutritional improvement.Methods:A randomized controlled trial was conducted on 100 eligible patients with damp-heat downward syndrome after low fistula-in-ano surgery.Patients were randomly divided into an experimental group and a control group,with 50 patients in each group.The control group received conventional treatment,while the experimental group was additionally treated with oral MHJD.Changes in inflammatory markers(CRP,WBC),immune cell function(CD3+,CD4+),and quality of life(SF-36 score)were observed before and after treatment,and wound healing time was compared between groups.Results:The experimental group showed significantly shorter wound healing times than the control group(P<0.001).On postoperative days 7 and 14,CRP,WBC,and NEUT%levels were significantly lower in the experimental group compared to the control group(P<0.05).On day 14,CD3+,CD4+,CD8+,NK cells,and B cell ratios were significantly higher in the experimental group(P<0.05).VAS pain scores on days 1,3,7,14,and 21 were significantly lower in the experimental group(P<0.05),and the frequency and dosage of analgesics used were also significantly lower(P<0.05).On days 14 and 30,the SF-36 quality of life scores were significantly higher in the experimental group across all dimensions(P<0.05).On day 14,serum albumin,prealbumin,and transferrin levels were significantly higher,while IL-6,TNF-α,and IFN-γ levels were significantly lower in the experimental group(P<0.05),with no significant changes in liver and kidney function indicators(P>0.05).Conclusion:Modified Huanglian Jiedu Decoction promotes wound healing,reduces postoperative pain,and improves quality of life in patients with damp-heat downward syndrome after low fistula-in-ano surgery by exerting anti-inflammatory,immune-modulating,and nutritional enhancement effects.关键词
加味黄连解毒汤/低位肛瘘术后/创面愈合/抗炎/湿热下注Key words
Modified Huanglian Jiedu Decoction/Low fistula-in-ano surgery/Wound healing/Anti-inflammation/Dampness-heat pouring downward
