中医药信息2025，Vol.42Issue(2)：69-75,7.DOI:10.19656/j.cnki.1002-2406.20250212
经典复方从铁死亡途径防治膝骨关节炎的案例分析——以独活寄生汤为例
Case Analysis of Classic Formulas for Preventing and Treating Knee Osteoarthritis via the Ferroptosis Pathway:A Study on Duhuo Jisheng Decoction
摘要
Abstract
Knee osteoarthritis(KOA)is a prevalent and complex degenerative joint disease characterized by pathological manifestations such as cartilage damage,synovial inflammation,and osteophyte formation,commonly affecting the elderly population.Ferroptosis,a newly discovered form of regulated cell death distinct from apoptosis,has emerged as a promising therapeutic target in recent years.The regulation of ferroptosis by Chinese medicine and compound formulas has become a research hotspot.This review systematically analyzes the mechanism of ferroptosis in KOA and the potential of Duhuo Jisheng Decoction in treating this condition by regulating ferroptosis-related pathways.The findings suggest that ferroptosis holds significant potential as a therapeutic target for KOA.Duhuo Jisheng Decoction,a classic formula widely used in traditional Chinese medicine for KOA treatment,impacts disease progression by modulating mechanisms such as iron metabolism disorders,oxidative stress,lipid peroxidation,and inflammatory responses involved in ferroptosis.关键词
膝骨关节炎/独活寄生汤/铁死亡Key words
Knee osteoarthritis/Duhuo Jisheng Decoction/Ferroptosis引用本文复制引用
张媛媛,姜帆,曾元宁,孙延平,王秋红..经典复方从铁死亡途径防治膝骨关节炎的案例分析——以独活寄生汤为例[J].中医药信息,2025,42(2):69-75,7.基金项目
国家"重大新药创制"科技重大专项项目(2018ZX09731-001) （2018ZX09731-001）
黑龙江省"头雁"团队支持项目([2019]5号) （[2019]5号）
国家重点研发计划项目(2018YFC1707100) （2018YFC1707100）
