中医药信息2025，Vol.42Issue(2)：82-87,6.DOI:10.19656/j.cnki.1002-2406.20250214
中药单体治疗肌少症的机制研究进展
Research Progress on Mechanisms of Traditional Chinese Medicine Monomers in the Treatment of Sarcopenia
摘要
Abstract
Sarcopenia is a skeletal muscle disease characterized by the progressive decline in skeletal muscle mass and function.It is associated with inflammatory responses,oxidative stress,mitochondrial dysfunction,autophagy changes in muscle cells,and satellite cell impairment.Classified under the categories of"wilting syndrome",and"consumptive disease"in Traditional Chinese Medicine(TCM),we found that sarcopenia can be effectively prevented and treated with TCM monomers.Compared with hormones,TCM monomers offer significant therapeutic benefits and greater safety.Monomers such as curcumin,atractylenolide I,icariin,and calycosin have been shown to improve muscle satellite cell function,mitochondrial activity,inflammatory and oxidative stress responses,and insulin resistance.They also delay skeletal muscle atrophy,enhance muscle strength,and improve muscle function,thereby preventing and mitigating the development of sarcopenia.关键词
中药/肌少症/骨骼肌萎缩/骨骼肌再生/机制/研究进展Key words
Traditional Chinese medicine/Sarcopenia/Skeletal muscle atrophy/Skeletal muscle regeneration/Mechanism/Research progress引用本文复制引用
刘芳,黄楠,杨佳明,陈龙,涂嘉欣,钟燕彪,罗云,王茂源..中药单体治疗肌少症的机制研究进展[J].中医药信息,2025,42(2):82-87,6.基金项目
国家自然科学基金项目(82060420) （82060420）
江西省自然科学基金项目(20212BAB206004) （20212BAB206004）
赣州市科技局重大项目(2023LNS37155) （2023LNS37155）
赣南医科大学心脑血管疾病防治教育部重点实验室(NX202022) （NX202022）
