北京生物医学工程2025，Vol.44Issue(1)：32-38,7.DOI:10.3969/j.issn.1002-3208.2025.01.005
基于孟德尔随机化探究尿酸盐与肾功能损伤风险的因果关系
Investigating the causal relationship between urate and the risk of renal function impairment by mendelian randomization
摘要
Abstract
Objective A causal relationship between Urate and renal impairment including decreased glomerular filtration rate function,abnormal serum urea nitrogen levels,and elevated urinary albumin/creatinine ratio is investigated based on Mendelian randomization.Methods Based on the Genome-wide association data of urate and renal function impairment diseases,the mononucleotide polymorphism loci between the two traits were found,and the parameters P＜5×10-8,linkage imbalance r2=0.001,and genetic region width of 10000 kb were set.Five Mendelian randomization methods,including inverse variance weighting method,MR-Egger regression method,weighted median method,simple model-based estimation and model-based weighted estimation,were used to conduct Mendelian randomization analysis,and were verified and analyzed by heterogeneity test,horizontal pleotropy test and one by one elimination sensitivity test.Results After removing confounding factors,78 instrumental variables related to urate were selected.Inverse variance weighted results showed that there was a causal relationship between urate and glomerular filtration rate(OR=0.971,95％CI=0.954-0.988).As urate level increased in the body,glomerular filtration rate function decreased.There was no causal relationship between urate and blood urea nitrogen levels(OR=1.025,95％CI=1.011-1.040),and no causal relationship between urate and increased urinary albumin/creatinine ratio(OR=1.000,95％CI=0.968-1.034).Conclusions Using Mendelian randomization to exclude confounding factors,the results showed that urate was causally and negatively correlated with the function of glomerular filtration rate,and that urate was clinically associated with blood urea nitrogen levels and elevated urinary albumin/creatinine ratio,but not causally.The results of this study are of great significance for early screening of renal injury,delaying the development of the disease and improving the long-term prognosis of patients.关键词
孟德尔随机化/肾功能损伤/尿酸盐/高尿酸血症Key words
mendelian randomization/renal function impairment/urate/hyperuricemia分类
医药卫生引用本文复制引用
孙天杰,王沁,何丽君,李婷婷..基于孟德尔随机化探究尿酸盐与肾功能损伤风险的因果关系[J].北京生物医学工程,2025,44(1):32-38,7.基金项目
上海市科委"青年科技英才扬帆"计划项目(21YF1418900)资助 （21YF1418900）
