集成电路与嵌入式系统2025，Vol.25Issue(2)：26-40,15.DOI:10.20193/j.ices2097-4191.2024.0078
微流控生物电阻抗传感检测芯片技术综述
Review on microfluidic bio-impedance sensing chip technologies
摘要
Abstract
With the advancement of research on single-cell heterogeneity,cellular electrophysical properties have become a crucial focus in disease diagnosis and precision medicine.Microfluidic bioelectrical impedance detection chips measure the impedance changes of cells in an electric field with high precision,enabling the label-free acquisition of cellular electrophysical characteristics such as cell size,mem-brane capacitance,and cytoplasmic conductivity.This significantly enhances the ability to detect cellular heterogeneity.Compared to traditional methods,microfluidic bioelectrical impedance detection chip technology offers advantages such as high sensitivity,simplicity of operation,and non-destructive detection,demonstrating broad application prospects in early disease diagnosis,drug screening,and personalized treatment.This review first elaborates on the basic principles and system design of the technology,then analyzes the pro-gress in optimizing microfluidic channels and electrode configurations,and discusses its applications in cell classification,drug evalua-tion,and other fields.Finally,the review examines current technical challenges and future development trends,highlighting its poten-tial for widespread application in precision medicine and early disease diagnosis.关键词
微流控/生物芯片/电阻抗检测/细胞电学特性/单细胞分析Key words
microfluidics/bio-chip/electrical impedance detection/cellular electrical characteristics/single-cell analysis分类
信息技术与安全科学引用本文复制引用
方文静,陈津,黄汐威,孙玲玲..微流控生物电阻抗传感检测芯片技术综述[J].集成电路与嵌入式系统,2025,25(2):26-40,15.基金项目
国家自然科学基金面上项目(62271184) （62271184）
浙江省自然科学基金重点项目(LZ22F010007) （LZ22F010007）
浙江省属高校基本科研业务费项目(GK249909299001) （GK249909299001）
国家重点研发计划青年科学家项目(2022YFD2000100). （2022YFD2000100）
