集成电路与嵌入式系统2025，Vol.25Issue(2)：41-54,14.DOI:10.20193/j.ices2097-4191.2024.0080
面向生物医疗应用的电刺激集成电路与系统综述
A review of integrated circuits and systems for electrical stimulation in biomedical applications
摘要
Abstract
Electrical stimulation technology has been widely applied in various biomedical fields,including cardiac pacemakers,cochlear implants,muscle reconstruction,vision restoration,and epilepsy suppression.Compared to traditional drug therapies or surgical meth-ods,electrical stimulation offers advantages such as reduced invasiveness,greater flexibility,improved recoverability,and the elimina-tion of risks associated with drug dependency and addiction.Due to the advantages of integrated circuits,including low power consump-tion,high reliability,strong programmability,ease of multifunctional integration,and suitability for mass production,they have re-cently become the primary choice for designing electrical stimulators,meeting the demands for miniaturized,intelligent,and cost-effec-tive biomedical applications.However,the integration of high-density electrodes with stimulation-generating circuits presents significant challenges in designing electrode-tissue interfaces.This paper begins with the electrode-tissue interface and provides a comprehensive o-verview of integrated circuit design for implantable electrical stimulators,including fundamental driver circuit topologies and high-per-formance complex designs.It emphasizes the analysis of the reliability and safety of biomedical implantable chips and introduces innova-tive designs that integrate stimulators with energy harvesting modules in closed-loop systems.This review also discusses the future di-rections of electrical stimulation technology and interface systems including our research group's work on electrical stimulation and inter-face circuits.关键词
集成电路/电刺激/电路与系统/神经接口Key words
integrated circuits/electrical stimulation/circuits and systems/neural interface分类
信息技术与安全科学引用本文复制引用
郑昊,周怡鑫,李霞光,王科平,吴家磊,尹思梦,秦锦哲,李紫菡,陈培栋,曹康康,李建业,潘彦洁..面向生物医疗应用的电刺激集成电路与系统综述[J].集成电路与嵌入式系统,2025,25(2):41-54,14.基金项目
国家自然科学基金资助(62371332 （）
U24B20163). （）
