集成电路与嵌入式系统2025，Vol.25Issue(2)：55-63,9.DOI:10.20193/j.ices2097-4191.2024.0079
面向脑类器官的微电极阵列技术发展现状及趋势
Current status and trends of microelectrode array for brain organoids
摘要
Abstract
Brain organoids are three-dimensional cell aggregates produced in vitro through the self-organization and differentiation of hu-man pluripotent stem cells,which can partially recapiculate the structure and function of the brain in humans.Microelectrode array(MEA)technology is capable of high-throughput detecting the electrophysiological activities of brain organoids with low damage,and high spatiotemporal resolution,thereby providing an efficient platform for the functional characterization of brain organoid neural net-works.The integration of brain organoids with MEA technology has attracted widespread attentions in the fields of nervous system de-velopment and disease mechanism research,biological neural network intelligent computing,and in vivo repair.In the area of nervous system development and disease mechanism research,MEA technology can long-term track the dynamic developmental process of brain organoids in real time and probe the pathogenesis of diseases by detecting the electrophysiological activities of brain organoids derived from various nervous system diseases.In the avenue of biological neural network intelligent computing research,brain organoids are ex-cellent computing devices attributed to their heterogeneous three-dimensional network structures and plasticity.Therefore,a highly effi-cient computing platform with low energy cost can be constructed through interaction of brain organoids with MEA.Furthermore,MEA technology shows potential technical application prospects in nervous system repair based on brain organoids.关键词
脑类器官/微电极阵列/神经系统疾病/神经计算/神经系统修复Key words
brain organoids/microelectrode arrays/neurological disease/neural computing/neural repair分类
信息技术与安全科学引用本文复制引用
肖禹,陈荣荣,陈康明,陈海松,林芃,何恩慧,纪俊峰..面向脑类器官的微电极阵列技术发展现状及趋势[J].集成电路与嵌入式系统,2025,25(2):55-63,9.基金项目
科技部国家重点研发计划项目(2023YFF1203600) （2023YFF1203600）
国家自然科学基金青年科学基金项目(62301483) （62301483）
浙江省"尖兵"研发攻关计划项目(2024C03001). （2024C03001）
