儿科药学杂志2025，Vol.31Issue(2)：5-11,7.DOI:10.13407/j.cnki.jpp.1672-108X.2025.02.002
基于网络药理学探讨小儿定喘口服液治疗儿童哮喘的作用机制
Mechanism of Xiao'er Dingchuan Oral Liquid in the Treatment of Children with Asthma Based on Network Pharmacology
摘要
Abstract
Objective:To explore the components,target information and network pharmacological mechanism of Xiao'er Dingchuan oral liquid in the treatment of children with asthma.Methods:Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),PubChem and SwissTargetPrediction databases were retrieved to predict the components and targets of Xiao'er Dingchuan oral liquid.On-line Mendelian Inheritance in Man(OMIM)and GeneCards databases were retrieved to obtain the asthma-related disease targets.Venn diagram was drawn on bioinformatics platform to output the common targets of drugs and diseases,and the"drug-component-target"network was constructed with CytoScape software to screen out the core components.Protein-protein interaction analysis was carried out in combination with STRING database and CytoNCA tool to screen out core targets.Gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analysis were performed for common targets by using DAVID database.Results:Totally 172 active components,931 targets,2,787 children's asthma targets,10 core components including glabridin,baicalin and wogonin,as well as 10 core targets including epidermal growth factor receptor(EGFR),interleukin-6(IL-6),and signal transduction and activator of transcription 3(STAT3)were screened out from Xiao'er Dingchuan oral liquid.There were 186 KEGG enrichment pathways,including phosphatidylinositol 3-kinase-protein kinase B(PI3K-Akt),mitogen activated protein kinase(MAPK),calcium ion and other signaling pathways.Conclusion:Xiao'er Dingchuan oral liquid plays an important role in the treatment of children with asthma through multi-components,multi-targets and multi-pathways.关键词
小儿定喘口服液/儿童/哮喘/网络药理学/作用机制Key words
Xiao'er Dingchuan oral liquid/children/asthma/network pharmacology/mechanism分类
医药卫生引用本文复制引用
郝梦缘,林荣军,刘冬云,韩振靓,路玲,金蓉..基于网络药理学探讨小儿定喘口服液治疗儿童哮喘的作用机制[J].儿科药学杂志,2025,31(2):5-11,7.基金项目
国家自然科学基金项目,编号81701587 （）
山东省中医药科技项目,编号M-2022227. （）
