儿科药学杂志2025，Vol.31Issue(2)：18-22,5.DOI:10.13407/j.cnki.jpp.1672-108X.2025.02.004
基于真实世界监测数据的山东省儿童严重药品不良反应可视化分析
Visualization Analysis of Severe Adverse Drug Reactions in Children of Shandong Based on Real-World Monitoring Data
摘要
Abstract
Objective:To visually analyze the characteristics and regularities of adverse drug reactions(ADR)in children,so as to provide reference for promoting the clinical safety of drug use in children.Methods:Statistical analysis was performed on severe ADR reports in children from the National Adverse Drug Reactions Monitoring System of Shandong.Social network analysis was performed to visualize correlation between the elements in ADR,system organ class(SOC)and drug combination networks.Results:Totally 6,811 severe ADR reports were retrieved.The number of pediatric patients decreased with age overall.Anti-infective drugs were the main category of drugs that cause severe ADR in children.There were 54 cases of high frequency drug combination,47 cases of high frequency ADR,and the common occurrence of skin and its appendages and systemic damage took the lead.Conclusion:Drugs should be selected rationally and hidden damage should be recognized by having general information about children,familiarizing with pharmacological characteristics,grasping the pattern of occurrence,strengthening pharmacological supervision and emphasizing drug combination to prevent and reduce severe ADR and promote the safe medication in children.关键词
药品不良反应/儿童用药/信息可视化技术/社会网络分析Key words
adverse drug reactions/medication in children/information visualization techniques/social network analysis分类
医药卫生引用本文复制引用
魏伟,权勤波,王维波..基于真实世界监测数据的山东省儿童严重药品不良反应可视化分析[J].儿科药学杂志,2025,31(2):18-22,5.基金项目
山东省药品不良反应监测哨点课题,编号2023SDADRKY45. （）
