儿科药学杂志2025，Vol.31Issue(2)：36-40,5.DOI:10.13407/j.cnki.jpp.1672-108X.2025.02.008
哌拉西林/他唑巴坦致儿童患者急性肾损伤的临床特征及影响因素分析
Clinical Characteristics and Influencing Factors of Acute Kidney Injury in Children Induced by Piperacillin/Tazobactam
摘要
Abstract
Objective:To analyze the incidence,clinical characteristics and influencing factors of acute kidney injury(AKI)in children induced by piperacillin/tazobactam in real world.Methods:Clinical data of children receiving piperacillin/tazobactam from Hengshui People's Hospital and Affiliated Hospital of Gansu Medical College from Jan.2023 to Jan.2024 were collected.The incidence,occurrence time,severity and prognosis of AKI were analyzed.Univariate analysis and multivariate logistic regression analysis were used to screen the influencing factors for AKI.Results:Totally 2,168 children were enrolled,and 75 cases(3.46％)developed AKI,the incidence of AKI in children ≤ 3 years was the highest(4.78％),and the incidence of AKI in children aged from＞7 to 18 years was the lowest(2.15％).The occurrence time of AKI was(5.59±3.18)d,the occurrence time of AKI in children ≤3 years was shorter than that in children from＞7 to 18 years,the severity of AKI was mainly stage Ⅰ(90.67％,68/75),the prognosis was better after drug withdrawal,the recovery time of renal function was(5.54±1.72)d.Univariate analysis showed that age ≤3 years,septic shock,24 h fluid overload,drug combination＞3 kinds of drugs,non-steroidal anti-inflammatory drugs,and low baseline serum creatinine clearance(Ccr)were the risk factors of AKI in children,multivariate analysis showed that age ≤ 3 years(OR=1.957),septic shock(OR=2.322),24 h fluid overload(OR=5.023),and drug combination＞3 kinds of drugs(OR=3.422)were independent risk factors of AKI in children.Conclusion:AKI induced by piperacillin/tazobactam is a common adverse drug reaction in children.Early detection and prevention of AKI have better prognosis.关键词
哌拉西林/他唑巴坦/儿童/急性肾损伤/临床特征/影响因素Key words
piperacillin/tazobactam/children/acute kidney injury/clinical characteristics/influencing factors分类
医药卫生引用本文复制引用
李光,张媛媛,王立丹,王伟美,脱鸣富,张亚玲..哌拉西林/他唑巴坦致儿童患者急性肾损伤的临床特征及影响因素分析[J].儿科药学杂志,2025,31(2):36-40,5.基金项目
甘肃省教育厅高校教师创新基金项目,编号2024B-216. （）
