儿科药学杂志2025，Vol.31Issue(2)：40-44,5.DOI:10.13407/j.cnki.jpp.1672-108X.2025.02.009
应用广义评估方程评价肤痒清凝胶治疗儿童湿疹的疗效
Efficacy Evaluation of Fuyangqing Gel in the Treatment of Children with Eczema Based on Generalized Estimating Equation Model
摘要
Abstract
Objective:To probe into the effective treatment of children with eczema.Methods:Retrospective analysis was performed on clinical data of 158 children with eczema admitted into the Inner Mongolia Baogang Hospital from Jun.2022 to Feb.2023.According to different treatment method,all patients were divided into the observation group(86 cases)and the control group(72 cases).The observation group was treated with cetirizine oral liquid combined with Fuyangqing gel,while the control group received cetirizine oral liquid.The treatment course was 28 d,and follow-up was performed every 7 d.Eczema area and severity index(EASI)score,clinical symptom score,skin lesion degree score,immune factor level and inflammatory factor level were compared before and after treatment at different time points.The generalized estimating equation model(GEE)was established to compare the difference of treatment effect at different time points and among different groups.Results:There was no significant difference between two groups in gender,age,course of disease,gastrointestinal fever,diet structure,disease history,allergy history,living environment,EASI score before treatment,clinical symptom score and skin lesion degree score(P＞0.05).Compared with before treatment,EASI score,clinical symptom score and lesion degree score decreased after treatment,and the improvement in observation group was better than that in control group(P＜0.05).The level of CD4+T and CD4+/CD8+T lymphocytes increased significantly,the level of CD8+T lymphocytes,interleukin(IL)-10 and IL-17 decreased significantly,and the changes in the observation group were more significant(P＜0.01).The total effective rate of observation group was 91.18％,higher than 80.33％of control group,with statistically significant difference(P＜0.05).Conclusion:The efficacy of cetirizine oral liquid combined with Fuyangqing gel in the treatment of children with eczema is significant,which is worthy of clinical promotion.关键词
肤痒清凝胶/儿童/湿疹/疗效/广义估计方程Key words
Fuyangqing gel/children/eczema/efficacy/generalized estimating equation分类
医药卫生引用本文复制引用
乔善鑫,陈培峰,魏海燕,徐萌,武力栋,薛寒梅,马亚琴..应用广义评估方程评价肤痒清凝胶治疗儿童湿疹的疗效[J].儿科药学杂志,2025,31(2):40-44,5.基金项目
内蒙古科技厅"十四五"重点研发与成果转化项目,编号2022YFSH0012. （）
