儿科药学杂志2025，Vol.31Issue(2)：44-48,5.DOI:10.13407/j.cnki.jpp.1672-108X.2025.02.010
布洛芬不同给药策略治疗早产儿动脉导管未闭的临床研究
Clinical Study on Different Administration Strategies of Ibuprofen in the Treatment of Premature Infants with Patent Ductus Arteriosus
摘要
Abstract
Objective:To compare the efficacy and safety of different administration strategies of ibuprofen in the treatment of premature infants with patent ductus arteriosus(PDA).Methods:A total of 184 premature infants diagnosed with hemodynamically significant patent ductus arteriosus(hsPDA)and treated with ibuprofen were retrospectively collected from Wenzhou Central Hospital from Jan.2022 to Jan.2024.The closure rate of PDA and complication rate of ibuprofen were analyzed according to different routes of administration,dosage,timing and duration of administration.Results:There was significant difference in closure rate of PDA between ibuprofen intravenous administration group and oral administration group(P＜0.05).There were no significant differences in the incidence of necrotizing enterocolitis(NEC),bronchopulmonary dysplasia(BPD),retinopathy of prematurity(ROP),intracranial hemorrhage(IVH),hyperbilirubinemia and feeding intolerance(FI)between ibuprofen intravenous administration group and oral administration group(P＞0.05).The incidence of oliguria and gastrointestinal bleeding in the ibuprofen intravenous administration group was significantly higher than that in oral administration group(P＜0.05).There were no significant differences in the closure rate of PDA and incidence of complication between the high dose and standard dose subgroup of oral administration group(P＞0.05).However,in intravenous administration group,the closure rate of PDA was higher in high dose subgroup than that in standard dose subgroup(P＜0.05),and the incidence of BPD and IVH was significantly lower than that in standard dose subgroup(P＜0.05).Both in oral and intravenous administration groups,the closure rate of PDA in＞7 to 14 d postnatal administration subgroup was higher than that in＞14 d postnatal administration subgroup(P＜0.05).In oral administration group,the incidence of NEC in ≤7 d postnatal administration subgroup was significantly higher than that in＞7 to 14 d postnatal administration subgroup(P＜0.05),the incidence of FI in ≤7 d postnatal administration subgroup was significantly higher than that in＞14 d postnatal administration subgroup(P＜0.05).While in intravenous administration group,the incidence of gastrointestinal bleeding in ≤7 d postnatal subgroup was significantly higher than that in＞7 to 14 d postnatal administration subgroup(P＜0.05).Both in oral and intravenous administration groups,the closure rate of PDA and incidence of ROP in two-course subgroup was significantly higher than that in single-course subgroup(P＜0.05).Conclusion:High dose ibuprofen was given intravenously from＞7 to 14 d after birth and repeated the second course of treatment after a single course of treatment failed,which could increase the closure rate of PDA while ensuring the safety,it can be used as optimal treatment strategy for PDA in premature infants in clinical practice.关键词
布洛芬/动脉导管未闭/并发症/早产儿Key words
ibuprofen/patent ductus arteriosus/complication/premature infants分类
医药卫生引用本文复制引用
曾婧婕,侯齐书,叶继锋,唐锦心..布洛芬不同给药策略治疗早产儿动脉导管未闭的临床研究[J].儿科药学杂志,2025,31(2):44-48,5.基金项目
2023年温州市基础性科研项目,编号Y2023927. （）
