西部中医药2025，Vol.38Issue(1)：7-10,4.DOI:10.12174/j.issn.2096-9600.2025.01.02
夏枯草提取物对糖脂代谢异常大鼠的影响
Effects of the Extracts of Xiakucao on Abnormal Glucose-lipid Metabolism in Rats
摘要
Abstract
Objective:To discuss the effects of the extracts of Xiakucao(Prunellae spica)on rats with abnormal glucose-lipid metabolism.Methods:SPF-grade Wistar male rats were divided into seven groups according to random number table method,that is,the blank group,the model group,lovastatin group,metformin group,high,moderate and low doses groups of the extracts of Xiakucao,after one week of routine feeding,the blank group was given conventional feeding,and the remaining six groups accepted high-sugar,high-fat diet for 30 days,to prepare the rat models with abnormal glucose-lipid metabolism.After successfully modeling,the medicine groups were drenched with 5.00,2.50 and 1.25 g/kg of the extract concentrate of Xiakucao,3.0 mg/kg of lovastatin and 200 mg/kg of metformin respectively,the blank group and the model group were given 10 mL/kg of distilled water by gavage,once each day,for 15 days in a row.Rats were anaesthetised with 2%pentobarbital sodium by intraperitoneal injection 24 h after the last dose and 12 h after fasting.The levels of blood glucose and glycated haemoglobin were detected after orbital blood sampling;femoral artery blood collection was adopted to measure the contents of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)in the serum.Results:Compared with the blank group,body mass,the levels of TC and TG,fasting blood glucose(FBG)and glycated haemoglobin were increased in the model group(P<0.05);compared with the model group,body mass,the contents of serum TC and TG were reduced in lovastatin group,high and moderate doses groups of the extracts of Xiakucao(P<0.05),the contents of serum LDL-C,blood glucose and glycated haemoglobin were lowered in lovastatin group,high,moderate and low doses groups of the extracts of Xiakucao(P<0.05),the contents of HDL-C were elevated(P<0.05);compared with lovastatin group,the increase in body mass,the contents of serum TC and TG,FBG and glycated haemoglobin could be seen in low dose group of Xiakucao(P<0.05).Conclusion:The extract of Xiakucao could effectively regulate and control body mass,blood lipid and blood glucose in rats with abnormal glucose-lipid metabolism,and the regulatory effects of high and moderate doses groups of the extracts of Xiakucao on the rats were more significant.关键词
糖脂代谢异常/总胆固醇/甘油三酯/夏枯草/大鼠Key words
abnormal glucose-lipid metabolism/total cholesterol/triglyceride/Xiakucao/rats分类
医药卫生引用本文复制引用
李晶,姚进龙,刘生肸,王一强..夏枯草提取物对糖脂代谢异常大鼠的影响[J].西部中医药,2025,38(1):7-10,4.基金项目
2021年甘肃省教育厅创新基金项目(2021A-314) （2021A-314）
2022年甘肃省教育厅创新基金项目(2022A-253). （2022A-253）
