西部中医药2025，Vol.38Issue(1)：25-28,4.DOI:10.12174/j.issn.2096-9600.2025.01.06
基于数据挖掘技术探讨王莘智教授治疗原发性干燥综合征的用药规律
Professor Wang Shenzhi's Medication Laws of Treating Primary Sjogren's Syndrome Based on Data Mining Technology
摘要
Abstract
Objective:To analyze professor Wang Shenzhi's medication laws of treating primary Sjogren's syndrome(pSS)based on data mining technology.Methods:Professor Wang Shenzhi's clinical cases of diagnosing and treating pSS were collected and sorted out,the prescriptions were entered into Excel 2010 to establish the database,the Ancient and Modern Medical Records Cloud Platform(V2.3)was used to conduct the frequency analysis and cluster analysis of herbs,association rules were analyzed using SPSS Modeler 18.0 software.Results:A total of 164 clinical prescriptions of professor Wang Shenzhi for the treatment of pSS were included,with 107 herbs,the core herbs with the frequency of more than 30%were Baizhu(Atractylodes macrocephala Koidz.),Huangqi(Astragali radix),Honghua(Carthami flos),Danggui(Angelicae sinensis radix),Xiakucao(Prunellae spica),and Fuling[Poria cocos(Schw.)Wol],Chaihu(Bupleuri Radix),Taoren(Persicae semen),Guizhi(Cinnamomum cassia Presl),Huangqin(Scutellariae radix),Cangzhu(Atractylodis rhizoma),Gancao(Glycyrrhizae radix et rhizoma),Xuanshen(Scrophulariae radix),Gouqizi(Lycii fructus),Fuzi(Aconiti lateralis radix praeparata),Shigao(Gypsum fibrosum)and Shudihuang(Rehmanniae radix praeparata).The herbs are mainly warm in nature,sweet,pungent and bitter in taste,attributed to the meridians of liver,lung and spleen,most of which could stabilize the fetus,moisten the intestine and promote the bowel movement,brighten the eyes,promote diuresis and alleviate swelling.Association rules have yielded 37 core drug combinations including Fuling-Baizhu,Xiakucao-Baizhu,Danggui-Baizhu.Cluster analysis classified the drugs into five clusters,which together performed the functions of tonifying the kidney and benefiting the essence,drying the dampness and strengthening the spleen,nourishing Yin and clearing heat,moving Qi and dredging the collaterals,invigorating the spleen and activating blood.Conclusion:Professor Wang Shenzhi adopts invigorating spleen and benefiting Qi as the core therapeutic method in the treatment of pSS,clearing liver and purging fire in the early stage,nourishing liver and kidney in the late stage,meanwhile combining with clearing heat and generating fluid,promoting blood circulation and removing the stagnation.关键词
原发性干燥综合征/用药规律/关联规则/聚类分析Key words
primary Sjogren's syndrome/medication laws/association rules/cluster analysis分类
医药卫生引用本文复制引用
许潜,俞赟丰,贺选玲,韦方敏,杨欣雨,王莘智..基于数据挖掘技术探讨王莘智教授治疗原发性干燥综合征的用药规律[J].西部中医药,2025,38(1):25-28,4.基金项目
湖南省自然科学基金(2020JJ4479) （2020JJ4479）
湖南中医药科研计划项目(B2024065) （B2024065）
湖南省中医药科研计划项目(201778). （201778）
