广西师范大学学报（自然科学版）2025，Vol.43Issue(1)：75-84,10.DOI:10.16088/j.issn.1001-6600.2024042903
桂花精油在延缓衰老中的作用探究
Study on Role of Osmanthus Essential Oil in Delaying Aging
摘要
Abstract
This study explores the anti-aging effects of osmanthus essential oil on human neuroblastoma SH-SY5Y cells and an acute aging mouse model.In vitro experiments,the anti-aging effects of osmanthus essential oil was assessed by measuring its impact on the expression of aging markers and the levels of reactive oxygen species(ROS)in SH-SY5Y cells.The results indicate that osmanthus essential oil at concentrations of 2-100 μg/mL is non-toxic to SH-SY5Y cells and significantly reduces H2O2-induced ROS levels and improved aging cell characteristics,including reducing the expression of senescence-associated secretory phenotype(SASP)genes and aging-related genes(P16,P53,and P21),and decreasing SA-β-gal production.The vivo experiments showed that different doses of osmanthus essential oil(0.012 5,0.025,and 0.05 μL/g)significantly increased antioxidant enzyme(SOD,CAT)activities in the serum of acutely aged mice,while reducing MDA and ROS levels.Combining the results in vitro and vivo experiments,osmanthus essential oil significantly delays the aging process in cellular and animal models through its potent antioxidant effects,providing strong scientific evidence for its application in anti-aging treatments.关键词
桂花/精油/抗衰老/抗氧化活性/动物模型Key words
Osmanthus fragrans/essential oil/anti-aging/antioxidant activity/animal models分类
化学化工引用本文复制引用
卢小倩,董秋伶,李安琪,吴琼..桂花精油在延缓衰老中的作用探究[J].广西师范大学学报（自然科学版）,2025,43(1):75-84,10.基金项目
广西重点研发计划项目(挂桂AB21196023) （挂桂AB21196023）
