海南医科大学学报2025，Vol.31Issue(2)：131-145,15.DOI:10.13210/j.cnki.jhmu.20240904.002
补肾活血中药改善帕金森病睡眠症状的网状Meta分析
Net Meta-analysis on Improvement of Sleeping Symptoms in Parkinson's Disease by Chinese Herbal Medicine for Kidney Replenishment and Blood Invigoration
摘要
Abstract
Objective:To explore the clinical efficacy of Bushen Huoxue traditional Chinese medicine on sleep symptoms in Parkinson's disease(PD).Methods:Computer searches of Chinese and English databases such as Zhi.com,Wanfang,Wipu,PubMed,Cochrane Library,Embase,sinomed,Medline,etc.were conducted to collect randomised controlled trials(RCTs)on the treatment of Parkinson's disease(PD)sleep by rennon-renal-boosting Chinese herbal medicines with a search timeframe of the period of library construction to July 2024.After literature screening and data extraction by two researchers through Note express software,RevMan 5.4 was used for risk of bias assessment,and Stata 18.0 was used for reticulation Meta-analysis.Results:A to-tal of 36 studies of RCTs were included,including 3 583 patients.The results of reticulated meta-analysis showed that in terms of improving the overall clinical effectiveness rate,the top three were ping trembling granules,Bushen Huoxue drink,and Bushen Huoxue soup,respectively;in terms of improving the PDSS,the top three were nourishing the kidney and ping trembling gran-ules,stopping trembling soup,and Bushen Huoxue granules;in terms of lowering the PSQI,the top three were Cistanches and relieving spasm granules,Bushen Huoxue soup,and Bushen Huoxue granules;and in terms of lowering the 5-HT In reducing 5-HT,the top three were Bushen Huoxue circulation formula,Bushen Huoxue granules,and Bushen Huoxue drink;in reducing UPDRS Ⅰ,the top three were self-designed Bushen Huoxue soup,nourishing the kidney and calming tremor formula,and Bush-en Huoxue circulation formula.In terms of improvement of adverse reactions,the top three were Stop Fibrillation Soup,Nourish-ing Kidney,Activating Blood and Shredding Liver Soup,and Tonifying Kidney,Activating Blood and Promoting Blood Granule.Conclusion:Based on the current evidence,it is proved that Chinese herbs that tonify the kidney and invigorate blood can improve the efficacy of treating sleep symptoms in patients with PD.Due to the limitation of the quality and number of included studies,the above findings still need to be verified by more large-sample,high-quality,direct-comparison studies.关键词
帕金森病/补肾活血/网状Meta/睡眠/疗效Key words
Parkinson's disease/Bushen Huoxue/Reticular meta/Sleep/Efficacy分类
医药卫生引用本文复制引用
李珣,丁琦,夏金言,刘颖,蔡晶..补肾活血中药改善帕金森病睡眠症状的网状Meta分析[J].海南医科大学学报,2025,31(2):131-145,15.基金项目
This study was supported by the National Natural Science Foundation of China(82074507) （82074507）
Joint Provincial Key Clinical Speciality Construction Project of Chinese Medicine Health Management(Geriatrics)(XJG2023016) （Geriatrics）
Fujian Provincial Natural Science Foundation(Key Project)(2023J02023) 国家自然科学基金(面上项目)(82074507) （Key Project）
中医健康管理学联合省级临床重点专科建设项目(老年病科)(XJG2023016) （老年病科）
福建省自然科学基金(重点项目)(2023J02023) （重点项目）
