海南医科大学学报2025，Vol.31Issue(2)：152-160,9.DOI:10.13210/j.cnki.jhmu.20241009.003
成骨细胞铁死亡与Nrf2-ARE的相互作用在骨质疏松防治领域的研究进展
Research progress on the interaction between osteoblast ferroptosis and Nrf2/ARE in the prevention and treatment of osteoporosis
摘要
Abstract
Osteoporosis is a metabolic bone disease characterized by decreased bone mass,increased bone fragility,and sus-ceptibility to fractures.Its occurrence depends on the dynamic balance between osteoblasts and osteoclasts.The inactivation of os-teoblasts is closely related to bone remodeling and the maintenance of bone homeostasis.As a new type of cell death,ferroptosis is mainly caused by iron accumulation and abnormal amino acid metabolism,which leads to an increase in the concentration of reac-tive oxygen species in cells,and then iron-dependent lipid peroxidation,inducing cell ferroptosis.Under oxidative stress,Nrf2,an important antioxidant nuclear transcription factor,can improve the antioxidant capacity of cells by activating downstream ARE-specific elements,thereby interfering with the ferroptosis process in osteoblasts.In this paper,the mechanism of iron-dependent cell death and related pathways mediating ferroptosis in osteoblasts are summarized,so as to broaden the ideas for the prevention and treatment of related diseases caused by bone homeostasis imbalance.关键词
骨质疏松症/铁死亡/Nrf2/ARE通路/成骨细胞/氧化应激/脂质过氧化Key words
Osteoporosis/Ferroptosis/Nrf2/ARE/Osteoblasts/Oxidative stress/Lipid peroxidation分类
医药卫生引用本文复制引用
靳博,章晓云,李勇进..成骨细胞铁死亡与Nrf2-ARE的相互作用在骨质疏松防治领域的研究进展[J].海南医科大学学报,2025,31(2):152-160,9.基金项目
This study was supported by National Natural Science Foundation of China(82360937) （82360937）
General Project of Guangxi Natural Science Foundation(2023GXNSFAA026075) （2023GXNSFAA026075）
Guangxi Graduate Education Innovation Program Project(YCSW2024428) 国家自然科学基金资助项目(82360937) （YCSW2024428）
广西自然科学基金面上项目(2023GXNSFAA026075) （2023GXNSFAA026075）
广西研究生教育创新计划项目(YCSW2024428) （YCSW2024428）
