海南医科大学学报2025，Vol.31Issue(3)：229-240,12.DOI:10.13210/j.cnki.jhmu.20241029.003
牙龈卟啉单胞菌干预慢性阻塞性肺疾病状态的研究进展
Research progress on the intervention of Porphyromonas gingivalis in chronic obstructive pulmonary disease
摘要
Abstract
When the host's defense system is unable to promptly eliminate microorganisms entering the lungs,oral microbiota can colonize the lungs and affect the lower respiratory tract's pulmonary function.Among oral microorganisms,Porphyromonas gingivalis(P.gingivalis)is a key pathogen associated with periodontal disease(PD),a chronic inflammatory condition character-ized by a high prevalence of periodontitis.Chronic obstructive pulmonary disease(COPD),on the other hand,is a chronic inflam-matory disease of the airways that occurs in the respiratory system.PD,mediated by P.gingivalis,influences the inflammatory re-sponse,and cell-mediated immunity,and activates oxidative stress as well as apoptosis pathways,thereby altering the pulmonary microbiome and establishing a close association with COPD,affecting its progression.This article focuses on the epidemiologic in-vestigation of PD and COPD and common risk factors,the pathways and key mechanisms by which the key causative agent of PD,P.gingivalis,affects the development of COPD,the impact of intervening P.gingivalis on the efficacy of COPD treact-ment,and the impact of P.gingivalis on other respiratory disorders,for the purpose of providing new treatment ideas for patients of PD accompanied with COPD.关键词
牙龈卟啉单胞菌/牙周炎/慢性阻塞性肺疾病/口腔微生物Key words
Porphyromonas gingivalis/Periodontitis/Chronic obstructive pulmonary disease/Oral microorganism分类
医药卫生引用本文复制引用
袁晴,董雨雷,郭竹玲..牙龈卟啉单胞菌干预慢性阻塞性肺疾病状态的研究进展[J].海南医科大学学报,2025,31(3):229-240,12.基金项目
This research was supported by the Young Scientists Fund of the National Natural Science Foundation of China(82201080) 国家自然科学基金青年科学基金项目(82201080) （82201080）
