江汉大学学报（自然科学版）2025，Vol.53Issue(1)：56-62,7.DOI:10.16389/j.cnki.cn42-1737/n.2025.01.007
3,5-二叔丁基水杨酸锌纳米粒的制备及其抗三阴性乳腺癌活性研究
Preparation of 3,5-di-tert-butylsalicylate Zinc Nanoparticles and Its Inhibitory Effect on TNBC
摘要
Abstract
Objective Zinc 3,5-di-tert-butylsalicylate[Zn(DTBS)2]has extremely low solubility in water and is prone to aggregation and precipitation,which reduces its efficacy.To overcome this defect,zinc 3,5-di-tert-butylsalicylate nanoparticles(ZnNPs)were prepared to improve the bioavailability of the raw drug and investigate its inhibitory effect on the activity of triple-negative breast cancer cells.Methods After ZnNPs were prepared by nanoprecipitation,the morphology,particle size,zeta potential,encapsulation efficiency,and drug loading of the nanoparticles were determined,and its inhibitory effect on human triple-negative breast cancer cells MDA-MB-231 was detected by MTS assay.Results ZnNPs had a solid spherical structure of uniform size,with diameter of(240±18)nm,ζ potential of(-35±8)mV,encapsulation efficiency of(82.66±1.98)%,and drug loading of(11.77±0.28)%.ZnNPs inhibited the activity of triple-negative breast cancer cells in a concentration-and time-dependent manner from the concentration of 50 μmol/L,and compared with the same concentration of free[Zn(DTBS)2],ZnNPs showed stronger anticancer activity.Conclusion ZnNPs can enhance the inhibitory effect of Zn(DTBS)2 on triple-negative breast cancer cell activity.关键词
3,5-二叔丁基水杨酸锌/纳米粒/三阴性乳腺癌/纳米沉淀法Key words
zinc 3,5-ditert-butylsalicylate/nanoparticles/triple-negative breast cancer(TNBC)/nanoprecipitation分类
医药卫生引用本文复制引用
陈铭,王东,陈恒,范丽梅,刘钰晨,柳昀熠..3,5-二叔丁基水杨酸锌纳米粒的制备及其抗三阴性乳腺癌活性研究[J].江汉大学学报（自然科学版）,2025,53(1):56-62,7.基金项目
国家自然科学基金项目(81602642) （81602642）
湖北省教育厅指导项目(B2019233) （B2019233）
江汉大学基础性科研项目(2021jczx-002) （2021jczx-002）
江汉大学高层次人才培育项目(3015/06210046) （3015/06210046）
