结核与肺部疾病杂志2025，Vol.6Issue(1)：55-60,6.DOI:10.19983/j.issn.2096-8493.2024145
超声引导下微波消融技术在局限性结核病变治疗中的价值分析
The value of ultrasound-guided microwave ablation in the treatment of localized tuberculous lesions
摘要
Abstract
Objective:This study aims to evaluate the clinical efficacy and potential applications of ultrasound-guided microwave ablation as an adjunct to conventional anti-tuberculosis pharmacotherapy in the management of localized tuberculous lesions.Methods:A retrospective analysis was conducted on 12 patients with localized tuberculous lesions who underwent ultrasound-guided microwave ablation at the Shandong Public Health Clinical Center and the Shandong First Medical University Affiliated Provincial Hospital between March 2020 and January 2023.The cohort included 6 cases of lymph node tuberculosis,4 cases of chest wall tuberculosis,and 2 cases of liver tuberculosis.Contrast-enhanced ultrasound(CEUS)was performed post-ablation for all patients to evaluate treatment efficacy.Follow-up assessments were carried out at 3,6,9,12,and 24 months post-ablation to measure the ablation lesion volume and calculate its reduction rate.Data were expressed as median(interquartile range,M(P25,P75))and analyzed using the Z-test to assess the effectiveness of the ablation procedure.Results:Contrast-enhanced ultrasound confirmed complete ablation in all 15 localized tuberculous lesions across 12 patients immediately after the procedure.During follow-up at 3,6,9,12,and 24 months post-ablation,the median lesion volumes were recorded as 2.82(1.62,5.85)cm3,1.95(1.54,4.59)cm3,1.62(0.15,4.02)cm3,1.52(0.00,3.98)cm3,0.00(0.00,1.64)cm3,respectively.Correspondingly,the shrinkage rates of the ablation lesions were 51(36,59)％,62(52,72)％,69(58,97)％,71(62,100)％,100(72,100)％.By the end of the follow-up period,8 ablation lesions had completely resolved.The reduction rate of ablation lesions at 24 months post-surgery was significantly higher compared to those at 3,6,9,and 12 months,with corresponding values of-3.41,-3.18,-3.06,and-2.52(P=0.001,0.001,0.002,and 0.012,respectively).No complications,such as peripheral organ damage,needle track implantation,or tuberculosis dissemination,were observed during or after the procedure.Furthermore,no active disease progression or recurrence was detected throughout the follow-up period.Conclusion:Ultrasound-guided micro wave ablation demonstrates significant efficacy and safety in the treatment of localized tuberculous lesions,highlighting its potential as a valuable minimally invasive therapeutic option deserving broader clinical application.关键词
结核/超声检查,介入性/治疗应用Key words
Tuberculosis/Ultrasonography,interventional/Therapeutic uses分类
医药卫生引用本文复制引用
阎庆虎,薛峰,于泳,秦毅,阎庆梅,崔嘉..超声引导下微波消融技术在局限性结核病变治疗中的价值分析[J].结核与肺部疾病杂志,2025,6(1):55-60,6.基金项目
山东省医药卫生科技项目(面上项目)(202309020993) Shandong Province Medical and Health Science and Technology Project(General Project)(202309020993) （面上项目）
