解放军医学院学报2024，Vol.45Issue(12)：1233-1239,7.DOI:10.12435/j.issn.2095-5227.2024.158
年轻乳腺癌患者乳腺动态增强磁共振成像特征和临床病理特征分析
Dynamic contrast-enhanced magnetic resonance imaging characteristics and clinicopathological features in young breast cancer patients
摘要
Abstract
Background The breast cancer in young patients are characterized by strong aggressiveness and poor prognosis.However,there are few studies on the dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)features of young breast cancer.Objective To investigate the MRI characteristics and clinicopathological features of young female breast cancer patients.Methods A retrospective analysis was conducted on female patients with invasive breast cancer treated in the Department of General Surgery of the First Medical Center of Chinese PLA General Hospital from January 2019 to December 2020.The patients were divided into young breast cancer group(25-40 years old)and non-young breast cancer group(41-81 years old).The preoperative breast DCE-MRI images and clinical pathological features were analyzed for both groups.Results Of the 333 cases,there were 63 cases in the young breast cancer group and 270 cases in the non-young breast cancer group.The young breast cancer group exhibited significant differences in several demographic and clinical variables compared to the non-young breast cancer group,including age,disease site,body mass index(BMI),menstrual status,and a history of hypertension(P＜0.05).Notably,the young breast cancer group displayed a higher incidence of non-mass enhancement(NME)on DCE-MRI(P=0.030),along with elevated levels of Ki-67 expression and a higher expression rate(both P＜0.05)when compared to the non-young breast cancer group.Furthermore,when compared to the young breast cancer mass enhancement subgroup,the young breast cancer non-mass enhancement subgroup had significantly lower expression levels of estrogen receptor(ER)(P=0.044),a lower high expression rate of progesterone receptor(PR)(P=0.047),and a lower rate of breast conserving surgery(P=0.011).Conclusion Young breast cancer patients exhibit unique clinical pathological features,with NME more commonly showing in breast MRI,which may be related to more invasive pathological types and poorer prognosis.关键词
乳腺癌/乳腺动态增强核磁/非肿块样强化/雌激素受体/孕激素受体/青年/女性Key words
breast cancer/dynamic contrast-enhanced magnetic resonance imaging/non-mass enhancement/estrogen receptor/progesterone receptor/young adult/female分类
医药卫生引用本文复制引用
陈思屹,陈玉辉,张丽萍,谢昱娇,杨子桐,郭诗琪,高兆凤,王建东..年轻乳腺癌患者乳腺动态增强磁共振成像特征和临床病理特征分析[J].解放军医学院学报,2024,45(12):1233-1239,7.基金项目
国家自然科学基金项目(GWJJ2021100303) （GWJJ2021100303）
