解放军医学院学报2024，Vol.45Issue(12)：1272-1277,6.DOI:10.12435/j.issn.2095-5227.2024.130
基于单细胞测序的胃癌从癌前病变进展为恶性肿瘤的潜在机制综述
Research advances on potential mechanisms of gastric cancer progression from precancerous lesion to malignant tumour based on the single-cell sequencing
摘要
Abstract
Gastric cancer(GC)is one of the leading causes of cancer-related deaths worldwide,and reducing the mortality rate has become an urgent public health issue.Elucidation of the underlying mechanisms by which gastric cancer evolves from a precancerous lesion to a malignant tumor is important for identifying key targets and blocking disease progression.Recently,important breakthroughs have been made in single-cell RNA transcriptome sequencing(scRNA-seq)technology.scRNA-seq can discriminate cellular heterogeneity and predict and analyze cell-cell interactions,identify novel mutations in cancer cells,explore the progressive epigenomic changes that occur during progression from precancerous to malignant tumors.Therefore,this paper describes the potential mechanisms of gastric cancer malignancy from the perspective of single-cell sequencing,focusing on the epithelial cell state and evolutionary dynamics during"malignant"progression of gastric cancer,the kinetic resolution of cell-cell interactions networks and changes in the TME of both non-malignant and malignant tissues,as well as the application of single-cell transcription in the evolutionary study of gastric cancer.关键词
胃癌/单细胞RNA测序/癌变/细胞异质性/肿瘤微环境Key words
gastric cancer/single-cell RNA sequencing/carcinogenesis/cellular heterogeneity/tumor microenvironment分类
医药卫生引用本文复制引用
原姚谦,陈倩倩,王佳凤,吕昆明,令狐恩强..基于单细胞测序的胃癌从癌前病变进展为恶性肿瘤的潜在机制综述[J].解放军医学院学报,2024,45(12):1272-1277,6.基金项目
"十四五"国家重点研发计划项目(2022YFC2503600) （2022YFC2503600）
