检验医学与临床2025，Vol.22Issue(4)：439-444,6.DOI:10.3969/j.issn.1672-9455.2025.04.002
早期糖尿病肾病影响因素的Meta分析
Meta-analysis of influencing factors for early diabetic nephropathy
摘要
Abstract
Objective To explore the main influencing factors for early diabetic kidney disease(DKD)and provide evidence-based support for the early identification and prevention of DKD.Methods A computer-based literature search was conducted in The Cochrane Library,Web of Science,PubMed,China National Knowledge Infrastructure(CNKI)and Wanfang databases for studies related to early DKD,with the search period from January 1 2009 to December 31 2023.Statistical analysis was performed using Stata 17.0 soft-ware.Results A total of 13 studies were included,with a total of 5 065 cases,including 1 405 patients with early DKD.The Meta-analysis results showed that the influencing factors for early DKD included disease dura-tion(OR=1.088,95%CI:1.029-1.150,P=0.003),body mass index(BMI,OR=1.097,95%CI:1.068-1.126,P<0.001),low-density lipoprotein cholesterol(LDL-C,OR=2.176,95%CI:1.760-2.692,P<0.001),fasting blood glucose(FBG,OR=1.410,95%CI:1.045-1.902,P=0.024),systolic blood pressure(SBP,OR=1.014,95%CI:1.008-1.020,P<0.001),hemoglobin A1c(HbA1c,OR=1.681,95%CI:1.298-2.177,P<0.001),left ventricular posterior wall thickness(LVPW,OR=2.773,95%CI:1.472-5.226,P=0.002)and interventricular septum thickness(IVS,OR=3.278,95%CI:1.679-6.401,P=0.001).Conclusion Disease duration,BMI,LDL-C,FBG,SBP,HbA1c,LVPW and IVS are all influencing fac-tors for early DKD.This study provides evidence-based support for clinical early warning and prevention of DKD.关键词
糖尿病肾病/Meta分析/影响因素/系统评价/早期Key words
diabetic kidney disease/Meta-analysis/influencing factor/systematic review/early分类
医药卫生引用本文复制引用
原茵,孙璇,岳树娇,刘颖,王泓午..早期糖尿病肾病影响因素的Meta分析[J].检验医学与临床,2025,22(4):439-444,6.基金项目
国家重点研发计划(2017YFC1703305) （2017YFC1703305）
国家重点基础研究发展计划(973计划,2011CB505406) （973计划,2011CB505406）
国家中医药管理局重点学科建设项目(zyyzdxk-2023008). （zyyzdxk-2023008）
