检验医学与临床2025，Vol.22Issue(4)：451-456,6.DOI:10.3969/j.issn.1672-9455.2025.04.004
重症肺炎患者SAA/CRP、活化蛋白C、CD64对病情转归的预测价值
Predictive value of SAA/CRP,activated protein C and CD64 for the outcome of patients with severe pneumonia
摘要
Abstract
Objective To observe changes in serum amyloid A(SAA)/C-reactive protein(CRP),activated protein C(APC)and cluster of differentiation 64(CD64)in patients with severe pneumonia,and to analyze the predictive value of these three indicators for disease outcome.Methods A total of 126 patients with severe pneumonia admitted to the hospital from October 2020 to October 2022 were selected prospectively as the study group,and 82 patients with common pneumonia were selected as the control group.All patients under-went laboratory tests upon admission,and the serum SAA/CRP,APC and CD64 were compared between the two groups.After admission,the study group received a systematic treatment and was followed up for 3 months to observe disease outcomes.The patients were divided into the recovery group and the non-recovery group.Clinical data and serological indicators were compared between the two groups.Logistic regression a-nalysis was performed to identify the factors influencing disease outcomes in patients with severe pneumonia.Receiver operating characteristic(ROC)curve was plotted to assess the predictive value of the three indicators for disease outcomes.Results The SAA/CRP and CD64 in the study group were higher than those in the con-trol group(P<0.05),and the level of APC was lower than that in the control group(P<0.05).Among the 126 patients with severe pneumonia,110 cases(87.30%)had favorable outcomes,while 16 cases(12.70%)did not.The SAA/CRP and CD64 in the non-recovery group were higher than those in the recovery group(P<0.05),and the level of APC was lower than that in the recovery group(P<0.05).Point-biserial correla-tion analysis revealed that SAA/CRP and CD64 were negatively correlated with disease outcomes in patients with severe pneumonia(r=-0.329,-0.414,P<0.05),while APC level was positively correlated with dis-ease outcomes(r=0.388,P<0.05).Logistic regression analysis indicated that SAA/CRP,CD64 and APC were identified as influencing factors for outcomes in severe pneumonia patients(OR=1.717,1.720,0.668,P<0.05).ROC curve analysis showed that the areas under the curve(AUC)for SAA/CRP,APC,and CD64 in predicting disease outcomes in severe pneumonia patients were 0.805,0.840 and 0.851 respectively,and the combined prediction AUC was greater at 0.957.Conclusion SAA/CRP and CD64 elevate,while APC level decrease in patients with severe pneumonia.The combined assessment of these three indicators can effectively predict the outcome of the patient's condition.关键词
重症肺炎/淀粉样蛋白A/C反应蛋白/活化蛋白C/簇分化抗原64Key words
severe pneumonia/amyloid A/C-reactive protein/activated protein C/cluster of dif-ferentiation antigen 64分类
医药卫生引用本文复制引用
冯琳琳,姚鲁肃..重症肺炎患者SAA/CRP、活化蛋白C、CD64对病情转归的预测价值[J].检验医学与临床,2025,22(4):451-456,6.基金项目
山东省优秀中青年科学家科研奖励基金项目(BS2020SW1379). （BS2020SW1379）
