检验医学与临床2025，Vol.22Issue(4)：457-460,465,5.DOI:10.3969/j.issn.1672-9455.2025.04.005
血清铁蛋白联合孕周对胎膜早破并发宫内感染的预测价值
Predictive value of serum ferritin combined with gestational week for premature rupture of membranes complicated by intrauterine infection
摘要
Abstract
Objective To evaluate the predictive value of serum ferritin and gestational week for intrauter-ine infection in women with premature rupture of membranes.Methods A retrospective analysis was conduc-ted on the clinical data of 137 women who delivered at this center from April 2019 to April 2021 with prema-ture rupture of membranes.The serum ferritin level and gestational week were recorded at the time of diagno-sis of premature rupture of membranes.After delivery,the degree of intrauterine infection was assessed,and the patients were grouped into the non-infection group and the infection group.The infection group was fur-ther divided into the mild infection group,the moderate infection group and the severe infection group.The gestational week and serum ferritin level were compared between the infection group and the non-infection group,as well as among the mild,moderate and severe infection subgroups.The correlation between serum ferritin level,gestational week and intrauterine infection in pregnant women with premature rupture of mem-branes was analyzed.Receiver operating characteristic(ROC)curve analysis was used to evaluate the predic-tive value of serum ferritin level and gestational week for intrauterine infection in women with premature rup-ture of membranes.Results The gestational week in the infection group was lower than that in the non-infec-tion group,while the serum ferritin level was higher in the infection group than that in the non-infection group,and the differences were statistically significant(P<0.05).The gestational week was the smallest in the severe infection group,followed by the moderate infection group and the largest in the mild infection group.There were statistically significant differences among the three groups(P<0.05).The serum ferritin level was highest in the severe infection group,followed by the moderate infection group,and lowest in the mild infection group.The differences among the three groups were statistically significant(P<0.05).The re-sults of the point biserial correlation analysis showed that serum ferritin and gestational week were associated with intrauterine infection in women with premature rupture of membranes(r=0.401,-0.310,P<0.05).Spearman correlation analysis also revealed a correlation between serum ferritin,gestational week and the se-verity of intrauterine infection in women with premature rupture of membranes(rs=0.828,-0.878,P<0.05).ROC curve analysis showed that the area under the curve(AUC)for predicting intrauterine infection in women with premature rupture of membranes by gestational week and serum ferritin alone and in combination were 0.720,0.818 and 0.839 respectively.Conclusion Gestational week and serum ferritin have certain pre-dictive value for intrauterine infection in women with premature rupture of membranes.Furthermore,the higher the serum ferritin level and the smaller the gestational week,the more likely intrauterine infection will occur in women with premature rupture of membranes.关键词
胎膜早破/宫内感染/铁蛋白/孕周/预测Key words
premature rupture of membranes/intrauterine infection/ferritin/gestational week/prediction分类
医药卫生引用本文复制引用
但跃,邹恋,陈佳,徐艳,殷溶..血清铁蛋白联合孕周对胎膜早破并发宫内感染的预测价值[J].检验医学与临床,2025,22(4):457-460,465,5.基金项目
重庆市科卫联合医学科研项目(2023QNXM019). （2023QNXM019）
