检验医学与临床2025，Vol.22Issue(4)：461-465,5.DOI:10.3969/j.issn.1672-9455.2025.04.006
重症肺结核患者SAA/CRP、IL-6水平及其临床意义
Clinical significance of SAA/CRP and IL-6 level in patients with severe pulmonary tuberculosis
摘要
Abstract
Objective To investigate the level of interleukin-6(IL-6),serum amyloid A(SAA)/C-reactive protein(CRP)and their clinical significance in patients with severe pulmonary tuberculosis,providing refer-ence for clinical diagnosis and treatment.Methods A total of 147 patients with pulmonary tuberculosis admit-ted to the Third People's Hospital of Kunming from January 2021 to August 2023 were selected as research subjects.According to the severity of the disease,the patients were divided into the severe group and the mild group.The clinical data,serum IL-6 level and SAA/CRP were compared between the different severity groups.The influencing factors of severe pulmonary tuberculosis were analyzed,and the correlation between serum IL-6,SAA/CRP and the severity of pulmonary tuberculosis was assessed.Receiver operating character-istic(ROC)curve analysis was used to evaluate the predictive value of serum IL-6 and SAA/CRP for severe pulmonary tuberculosis.Results There were significant differences in erythrocyte sedimentation rate(ESR),platelet-to-lymphocyte ratio(PLR)and platelet-to-white blood cell ratio(PWR)between the mild group and the severe group(P<0.05).The levels of serum IL-6,SAA,CRP and SAA/CRP in the severe group were higher than those in the mild group(P<0.05).PWR,PLR,IL-6 and SAA/CRP were identified as influencing factors for severe pulmonary tuberculosis(P<0.05).Serum IL-6 and SAA/CRP were positively correlated with the severity of pulmonary tuberculosis(r=0.560,0.483,P<0.05).Additionally,serum IL-6 level was positively correlated with SAA/CRP(r=0.657,P<0.05).The area under the curve(AUC)for the com-bined prediction of severe pulmonary tuberculosis by serum IL-6 and SAA/CRP was 0.927(95%CI:0.872-0.963).Conclusion PWR,PLR,IL-6 and SAA/CRP are all influencing factors of severe pulmonary tubercu-losis.Serum IL-6 and SAA/CRP are correlated with the severity of pulmonary tuberculosis.The combination of serum IL-6 and SAA/CRP has a higher predictive value for the progression of pulmonary tuberculosis to se-vere forms.关键词
肺结核/白细胞介素-6/淀粉样蛋白A/C反应蛋白/重症Key words
pulmonary tuberculosis/interleukin-6/amyloid A/C-reactive protein/severe分类
医药卫生引用本文复制引用
张琳,余彦廷,陈静,范稚坚..重症肺结核患者SAA/CRP、IL-6水平及其临床意义[J].检验医学与临床,2025,22(4):461-465,5.基金项目
云南省卫生健康委员会临床医学中心2020-2023年建设任务(ZX20201223). （ZX20201223）
