摘要
Abstract
Objective To investigate the relationship between reticulocyte count(Ret),mean corpuscular volume(MCV),mean corpuscular hemoglobin concentration(MCHC),iron metabolism indicators[serum transferrin(TRSF),ferritin(SF)]and renal anemia in uremic patients undergoing maintenance hemodialysis.Methods A total of 126 uremic patients undergoing maintenance hemodialysis from June 2021 to June 2023 were selected in the hospital as research subjects.Based on the presence or absence of renal anemia,patients were divided into the anemia group[hemoglobin(Hb)<110 g/L,80 cases]and the non-anemia group(Hb≥110 g/L,46 cases).The anemia group was further divided into the mild group(Hb>90 g/L),the moderate group(60<Hb≤90 g/L),and the severe(Hb≤60 g/L)group based on the severity of anemia.Ret,MCV,MCHC,TRSF and SF were measured and compared among the groups.The relationship between Ret,MCV,MCHC,TRSF,SF levels and anemia severity was analyzed.Receiver operating characteristic(ROC)curve a-nalysis was used to evaluate the diagnostic value of these indicators for renal anemia.Results The Ret in the anemia group was lower than that in the non-anemia group,while the MCV was higher than that in the anemia group,and the differences were statistically significant(P<0.05).There was no significant difference in MCHC between the two groups(P>0.05).The Ret in the mild group was higher than that in the moderate group and the severe group,and MCV was lower than that in the moderate group and the severe group,and the differences were statistically significant(P<0.05).The Ret in the moderate group was higher than that in the severe group,while MCV was lower than that in the severe group,and the differences were statistically significant(P<0.05).There was no significant difference in MCHC among the three groups(P>0.05).The levels of TRSF and SF in the anemia group were lower than those in the non-anemia group,and the differences were statistically significant(P<0.05).The levels of TRSF and SF in the mild group were higher than those in the moderate group and the severe group,and the levels of TRSF and SF in the moderate group were higher than those in the severe group,and the differences were statistically significant(P<0.05).Ret,TRSF and SF levels were negatively correlated with the severity of renal anemia(P<0.05),while MCV was positively cor-related with the severity of renal anemia(P<0.05).The areas under curves(AUC)for Ret,MCV,TRSF,and SF in diagnosing renal anemia in patients with maintenance hemodialysis uremia were 0.704,0.774,0.560 and 0.800 respectively.The AUC for the combined detection of all four indicators was larger(P<0.05).Con-clusion The Ret,MCV,TRSF and SF have auxiliary diagnostic value for renal anemia in uremic patients,and which are related to the severity of anemia in these patients.关键词
维持性血液透析/尿毒症/血红细胞参数/铁代谢/肾性贫血Key words
maintenance hemodialysis/uremia/erythrocyte parameter/iron metabolism/renal a-nemia分类
医药卫生
