检验医学与临床2025，Vol.22Issue(4)：470-474,5.DOI:10.3969/j.issn.1672-9455.2025.04.008
重组人干扰素α-2b阴道片联合聚焦超声治疗高危型HPV感染的疗效及对T细胞亚群、炎症因子的影响
Efficacy of recombinant human interferon α-2b vaginal tablets combined with focused ultrasound in the treatment of high-risk human papillomavirus infection and its effects on T cell subsets and inflammatory factors
摘要
Abstract
Objective To investigate the clinical efficacy of recombinant human interferon α-2b vaginal tab-lets combined with focused ultrasound in the treatment of high-risk human papillomavirus(HPV)infection,and to observe its effects on the HPV clearance rate,vaginal discharge cleanliness,T cell subsets and inflam-matory factors.Methods A total of 100 patients with high-risk HPV infection treated in the hospital from June 2022 to June 2023 were selected as study subjects.Patients were divided into the control group(treated with recombinant human interferon α-2b vaginal tablets)and the observation group(treated with recombinant human interferonα-2b vaginal tablets+focused ultrasound)using the random number table method,with 50 cases in each group.The HPV clearance rate and vaginal discharge cleanliness were compared between the two groups after treatment,as well as T lymphocyte subsets(proportion of CD4+T cells,proportion of CD8+T cells,CD4+/CD8+T cell ratio)and levels of inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6)procalcitonin(PCT)]before and after treatment in both groups.The overall effectiveness rate and inci-dence of adverse reactions were compared between the two groups.Results After treatment,the HPV clear-ance rate and the normal rate of vaginal discharge cleanliness in the observation group were significantly high-er than those in the control group(P<0.05).Additionally,the proportions of CD4+T cells and CD4+/CD8+T cell ratio were higher in the observation group,while the proportions of CD8+T cells,as well as the levels of CRP,IL-6 and PCT were lower in the observation group,compared with those in the control group,with all differences being statistically significant(P<0.05).Compared with the control group,the overall response rate was higher in the observation group(P<0.05),and the overall incidence of adverse reactions was lower in the observation group(P<0.05).Conclusion Recombinant human interferon α-2b vaginal tablets com-bined with focused ultrasound can increase the HPV clearance rate and normal rate of vaginal discharge clean-liness,improve immune function and inflammatory response,enhance treatment efficacy,and reduce the inci-dence of adverse reactions in patients.关键词
重组人干扰素α-2b阴道片/聚焦超声/高危型人乳头瘤病毒/CD4+T细胞/C反应蛋白/白细胞介素-6/降钙素原Key words
recombinant human interferon α-2b vaginal tablet/focused ultrasound/high-risk human papillomavirus/CD4+T cell/C-reactive protein/interleukin-6/procalcitonin分类
医药卫生引用本文复制引用
孙琮,刘静,刘琦,乔丽..重组人干扰素α-2b阴道片联合聚焦超声治疗高危型HPV感染的疗效及对T细胞亚群、炎症因子的影响[J].检验医学与临床,2025,22(4):470-474,5.基金项目
山东省淄博市医药卫生科研项目(20230501061). （20230501061）
