麻醉安全与质控2025，Vol.7Issue(1)：23-27,5.DOI:10.3969/j.issn.2096-2681.2025.01.006
麻醉意识指数指导环泊酚全身麻醉诱导的安全性和有效性
The safety and effectiveness of anesthesia consciousness index in guiding the induction of general anesthesia with ciprofol
摘要
Abstract
Objective To evaluate the safety and effectiveness of anesthesia consciousness index(Ai)in monitoring the induction of general anesthesia with ciprofol.Methods A total of 82 inpatients,aged 18-60 years,BMI 18-30 kg/m2,ASA Ⅰ or Ⅱ,receiving non-cardiac or non-neurosurgical elective surgery under general anesthesia with endotracheal intubation in Gansu Provincial Hospital from October 2023 to January 2024 were randomly divided into propofol group(n=41)and ciprofol group(n=41).During anesthesia induction period,propofol group was given 1.5-2.5 mg/kg propofol,ciprofol group was given 0.4 mg/kg ciprofol,and other anesthesia induction drugs were the same.Safety indicators:(1)changes in mean arterial pressure(MAP)and heart rate(HR)before induction(T0),before endotracheal intubation(T1),1 min after endotracheal intubation(T2),3 min after endotracheal intubation(T3),and 5 min after endotra-cheal intubation(T4);(2)cardiovascular adverse events and complications(body movement,choking,tearing)at T0,T,,T2,T3,T4.Effective indicators:(1)Ai were recorded before anesthesia induction(t0),2 min after anesthesia induction(t1),4 min after anesthesia induction(t2),6 min after anesthesia induction(t3),8 min after anesthesia induction(t4),10 min after anesthesia induction(t5),15 min after anesthesia induction(t6);(2)the rate of successful induction of general anesthesia.Results There was no significant difference in MAP between the two groups at each time point(P＞0.05).There was a statistically significant difference in heart rate at T4 between the two groups(P＜0.05).There were statistically significant differences in systolic hypotension and diastolic hypotension between the two groups at T1(P＜0.05),and there were statistically significant differences in sinus tachycardia between the two groups at T2(P＜0.05).While there was no significant difference in cardiovascular adverse events between the two groups at other time point(P＞0.05).There was significant difference in Ai between the two groups at t1 and t6(P＜0.05).The success rate of anesthesia induc-tion of both groups were 100％.Conclusion Under the guidance of Ai,0.4 mg/kg ciprofol is safe and effective during the induction of general anesthesia.Patients are well tolerated and hemodynamically stable during induction.关键词
环泊酚/麻醉意识指数/气管插管/安全性/有效性Key words
ciprofol/anesthesia consciousness index/tracheal intubation/safety/effectiveness引用本文复制引用
任冬青,李霞,李婷,石磊,李瑞丰,阎文军,朱磊..麻醉意识指数指导环泊酚全身麻醉诱导的安全性和有效性[J].麻醉安全与质控,2025,7(1):23-27,5.基金项目
甘肃省麻醉与脑功能临床医学研究中心项目(21JR7RA675) （21JR7RA675）
甘肃省人民医院科技创新平台基金项目(ZX-62000001-2021-260) （ZX-62000001-2021-260）
