南京师大学报（自然科学版）2025，Vol.48Issue(1)：47-55,9.DOI:10.3969/j.issn.1001-4616.2025.01.007
siRNA无载体递送研究进展
Study Advance in siRNA Carrier-Free Delivery
摘要
Abstract
Small interfering RNA(siRNA),as an important molecule capable of specific gene silencing,holds great promise in various applications.However,the effective delivery of siRNA has always been one of the key issues for its clinical application.Traditional siRNA delivery systems often rely on carrier vehicles,but these carriers have potential issues such as degradation,long-term toxicity and immune response,which restrict their clinical use.Therefore,carrier-free delivery of siRNA has become one of the research hotspots.This review aims to summarize the latest advances in siRNA carrier-free delivery research,including mechanism of action,delivery strategies and delivery advantages.关键词
小干扰RNA/无载体递送/RNA干扰/修饰策略/siRNA偶联物Key words
siRNA/carrier-free delivery/RNA interference/modification strategy/siRNA conjugates分类
医药卫生引用本文复制引用
刘珂瑶,罗应楠,胡一雪,王东纳,张列峰..siRNA无载体递送研究进展[J].南京师大学报（自然科学版）,2025,48(1):47-55,9.基金项目
国家自然科学基金项目(21877061). （21877061）
