肿瘤预防与治疗2025，Vol.38Issue(1)：42-49,8.DOI:10.3969/j.issn.1674-0904.2025.01.006
原发性前列腺鳞癌1例:个案报道暨文献复习
Primary Prostate Squamous Cell Carcinoma:A Case Report and Litera-ture Review
摘要
Abstract
Objective:Primary prostate squamous cell carcinoma(PSCC)is a rare disease with a limited response to treatment and a poor prognosis,with a median survival time of approximately 14 months.This study aims to gather and ana-lyze the clinicopathological,diagnostic,and treatment data of PSCC patients in China.Methods:Patients diagnosed as primary PSCC published from January 2001 to December 2023 were gathered from China National Knowledge Infrastructure Database and Wanfang Database.These patients were then in-cluded in a retrospective cohort study,along with one patient treated by our team,to analyze their clinical manifestations,pathology and prognosis.Survival analysis was conducted using the Kaplan-Meier method.Results:Among the 29 patients diagnosed as PSCC,16(55.1％)resided in coastal areas.The median age of onset was 66 years(ranging from 47 to 87).The main symptom for 25 patients(86.2％)was difficulty in urination.Only 1 patient(3.5％)had an elevated prostate specific antigen level.Poor differentiation was observed in 10 patients(34.4％),while moderate and well differentiation was seen in 17 patients(58.6％).Metastasis was present at the time of diagnosis in 14 patients(48.2％),with 13(44.8％)in stage Ⅰ-Ⅱ and 16(55.1％)in stage Ⅲ-Ⅳ.Radical prostatectomy was performed on 55 patients,8 received chemotherapy,and 14 underwent radiotherapy.Prognosis was not reported for four patients,while 16 had stable conditions and survived.9 patients passed away.Survival analysis indicated a significant correlation between radiotherapy and survival(P=0.020).Conclusion:Combined with a case of PSCC diagnosed and treated in our department,this study offers a comprehensive over-view of the clinicopathological features,diagnostic methods,and treatment approaches for reported primary PSCC in China,in-dicating that PSCC is usually advanced and metastatic when diagnosed,and the prognosis is poor.The use of radiotherapy has shown promise in reducing tumor recurrence and enhancing the overall prognosis for individuals with PSCC.关键词
前列腺恶性肿瘤/放疗/诊断Key words
Malignant tumors of the prostate/Radiotherapy/Diagnosis分类
医药卫生引用本文复制引用
韩兴月,李曾,周术奎,吴毅,肖英明,刘金鹏,杨盛柯,廖洪..原发性前列腺鳞癌1例:个案报道暨文献复习[J].肿瘤预防与治疗,2025,38(1):42-49,8.基金项目
This study was supported by grants from Science and Technology Department of Sichuan Province(No.2020YFS0421)and Health Commission of Sichuan Province(No.2023LCYJ004). 四川省科技厅重点研发项目(编号:2020YFS0421 （No.2020YFS0421）
四川省卫生健康委员会医学科技项目(编号:2023LCYJ004) （编号:2023LCYJ004）
