摘要
Abstract
Objective:To investigate the clinicopathological characteristics,treatment and prognosis of esophageal mixed neuroendocrine-non-neuroendocrine neoplasms(MiNENs),and deepen the understanding of the disease.Methods:The clinicopathological features,immunophenotype,treatment and prognosis of two esophageal MiNENs were also retrospectively reviewed with literature.Results:Two patients were quinquagenarian and elderly men who were treated for progressive dys-phagia and underwent radical resection of esophageal cancer after being pathologically confirmed as poorly differentiated car-cinoma.Microscopically,both two cases of tumors were composed of two types of heterotypic cells with no clear boundary.One kind of tumor cells were slightly larger,slightly red in cytoplasm,cells in small focal areas had intercellular bridge,this kind of tumor cells were continuous with the severely dysplasic squamous epithelium on the mass surface;the other kind of tumor cells were small,arranged in monotonous sheets,the nuclears were round or oval,with"salt and pepper"chromatin with less cytoplasm.Either proportion of the two tumor cells were more than 30％.Immunohistochemistrically,large tumor cells were characterized by AEl/AE3(cytoplasm+),P63(+),CK5/6(+)and p40(+),and small tumor cells by AE1/AE3(paranuclear punctate+),Syn(+),CgA(+)and CD56(+).Combined with morphological and immunohisto-chemical results,the two cases of tumors were clinically diagnosed as MiNENs which were composed of small-cell neuroendo-crine carcinoma and moderately or poorly differentiated squamous cell carcinoma.There were 4 reports meeting the diagnostic criteria of esophageal MiNENs in literature,there were a total of 6 cases,including the 2 cases in our study.All the 6 cases were male,and aged 53～92 years.The clinical manifestations were dysphagia or sternal pain after eating,with neither spe-cific imaging,nor endoscopic and clinical manifestations.All patients were treated surgically and confirmed by postoperative pathological examination.Conclusion:Esophageal MiNENs are very rare and have poor prognosis,which can be diagnosed by histological morphology and immunohistochemistry.关键词
食管/混合性神经内分泌-非神经内分泌肿瘤/免疫组化/治疗/预后Key words
Esophagus/Mixed neuroendocrine-non-neuroendocrine neoplasms/Immunohistochemistry/Treatment/Prog-nosis分类
医药卫生
