摘要
Abstract
Objective:To explore the influence of tumor history on the treatment compliance and glucose and lipid metab-olism in type 2 diabetes(T2DM)patients.Methods:100 T2DM patients with a history of malignant tumors in the depart-ment of endocrinology in our hospital from January 2018 to December 2022 were selected as the case group.A ratio of 1:2 was used to select 200 T2DM patients without history of tumors who were matched in sex,age,and course of disease during the same time of admission as the control group.The effects of tumor history on treatment compliance and on the levels of glu-cose and lipid metabolism indicators were compared between two groups.t-test,x2 test or rank sum test were used for inter-group comparison.Spearman rank correlation was used for correlation analysis.Results:The 8-item Morisky Medication Ad-herence Scale(MMAS-8)score of T2DM patients with a history of malignant tumors was significantly lower than that of T2DM patients without a history of tumors(6.01±1.76 vs 7.33±1.98,P＜0.001).There was a difference in the degree of medication adherence between the two groups(P＜0.001).The fasting plasma glucose(FPG)and glycated hemoglobin(HbA1C)of T2DM patients with a history of malignant tumors were significantly higher than those of the T2DM patients with-out a history of tumors,while the HDL-C of the former was lower than that of the latter,with statistical significance(all P＜0.05).The history of malignant tumors was negatively correlated to MMAS-8 score and HDL-C(r=-0.322,r=-0.165,P＜0.05),and was positively correlated to FPG and HbA1C(r=0.180,r=0.210,P＜0.05).Conclusion:T2DM patients with a history of malignant tumors have lower treatment compliance,higher levels of FPG and HbA1C,and lower levels of HDL-C.The evaluation and control of tumor-related hyperglycemia should be carried out based on the history of malignant tumors,the main cause of tumor-related hyperglycemia.关键词
糖尿病,2型/恶性肿瘤/治疗依从性/糖代谢/脂代谢Key words
Diabetes,type 2/Malignant tumor/Treatment compliance/Glucose metabolism/Lipid metabolism分类
医药卫生
