摘要
Abstract
Objective:To investigate the correlation between Chinese medicine patterns and serum miRNA-183(miR-183),interleukin-17(IL-17),IL-33 and soluble human stromal lysin 2(sST2)levels in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:Ninety-two AECOPD patients admitted to our hospital from January 2022 to December 2023 were selected as the study group,and 83 healthy medical checkups during the same period were selected as the control group,and serum miR-183,IL-17,IL-33 and sST2 levels of the two groups were tested and compared.The pa-tients in the study group were categorized into three groups:phlegm-heat lung syndrome,phlegm-fluid lung syndrome,and lung-kidney qi deficiency syndrome,with reference to the"Internal Medicine of Traditional Chinese Medicine"and the"Guide-lines for the Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease in Traditional Chinese Medicine".Tests were per-formed to compare the differences in lung function and levels of miR-183,IL-17,IL-33,and sST2 in patients with different TCM certificates.Results:Compared with the control group,the levels of miR-183,IL-17,IL-33and sST2 were higher in the study group,and the difference was statistically significant(P＜0.05).Among the 92 patients with AECOPD,there were 33 cases of phlegm-heat lung syndrome,28 cases of phlegm-heat lung syndrome,and 31 cases of lung and kidney qi deficiency syndrome.The first second expiratory volume with exertion(FEV1)and the first second expiratory volume with exertion as a percentage of predicted value(FEV1％)were lower in the Lung and Kidney deficiency syndrome than in the Phlegm-Heat-Depression of Lungs and Phlegm-Turbidity-Congestion of Lungs syndromes(P＜0.05),and there was no significant difference in the comparison of first second expiratory volume with exertion as a percentage of exerted lung capacity(FEV1/FVC)among the three Chinese medi-cine syndromes(P＞0.05).Serum miR-183,IL-17,IL-33 and sST2 levels were higher in the Lung and Kidney Qi Deficiency syndrome than in the Phlegm Turbidity and Lung Congestion syndrome and the Phlegm-Heat and Lung Depression syndrome,and the above indexes were higher in the Phlegm-Heat and Lung Depression syndrome than in the Phlegm-Turbidity and Lung Con-gestion syndrome(P＜0.05).Conclusion:Serum miR-183,IL-17,IL-33 and sST2 levels in AECOPD patients all showed some correlation with TCM evidence type,which can be used as an auxiliary tool for TCM evidence typing.关键词
慢性阻塞性肺疾病急性加重期/中医证型/miRNA-183/白细胞介素-17/白细胞介素-33/可溶性人基质裂解素2Key words
Acute exacerbation of chronic obstructive pulmonary disease/Chinese medicine evidence/miRNA-183/Inter-leukin-17/Interleukin-33/Soluble suppression of tumorigenicity 2分类
医药卫生
