上海交通大学学报（医学版）2025，Vol.45Issue(1)：51-59,9.DOI:10.3969/j.issn.1674-8115.2025.01.006
戒毒人员精神病理症状与药物成瘾的关系及心理痛苦的中介作用
Relationship between psychopathological symptoms and drug addiction,and mediating role of psychological distress in drug addicts
摘要
Abstract
Objective·To identify different comorbidity types resulting from the spontaneous association of psychopathological symptoms among male drug addicts,explore the relationship between latent types and drug addiction,and examine the mediating role of psychological distress.Methods·Four hundred and fifty male drug addicts,recruited by Yunnan First Compulsory Isolation Drug Rehabilitation Center according to the 2017 revised Drug Addiction Identification Method by the Ministry of Public Security,were enrolled as participants.The Symptom Checklist-90(SCL-90),Craving Automated Scale for Substances(CAS-S),and Psychache Scale(PAS)were used to assess the severity of psychopathological symptoms,drug addiction,and psychological distress,respectively.Latent class analysis was employed to identify different types of psychopathological comorbidity that may exist in the participants,and the types were named based on the analysis results.Variance analysis was used to test differences in the severity of drug addiction and psychological distress among different latent types,and a mediation model was established to explore the mediating role of psychological distress between different latent types and drug addiction.Results·Latent class analysis identified three types of psychopathology:high,medium,and low levels,with decreasing positive rates and numbers of comorbidity in each type based on the ten psychopathological symptoms included in the SCL-90.There were significant differences in the severity of psychological distress and drug addiction among the three types of participants.Psychopathological symptoms positively predicted the severity of psychological distress and drug addiction.Psychological distress completely mediated the relationship between medium levels of psychopathology and drug addiction,while partially mediating the relationship between high levels of psychopathology and drug addiction.Conclusion·There are three types of psychopathological comorbidity among male drug addicts:high,medium,and low.Psychological distress plays a complete mediating role between medium levels of psychopathology and drug addiction,and a partial mediating role between high levels of psychopathology and drug addiction.关键词
药物成瘾/精神病理症状/心理痛苦/共病/潜在类别分析Key words
drug addiction/psychopathological symptoms/psychological distress/comorbidity/latent class analysis分类
医药卫生引用本文复制引用
高雨燕,李伟,王书婷,岸本鹏子,张洳源..戒毒人员精神病理症状与药物成瘾的关系及心理痛苦的中介作用[J].上海交通大学学报（医学版）,2025,45(1):51-59,9.基金项目
国家自然科学基金(32100901). National Natural Science Foundation of China(32100901). （32100901）
