武警医学2025，Vol.36Issue(1)：16-20,5.
乳腺癌血管生成拟态和免疫微环境关系的初步探索
Preliminary exploration of the relationship between vasculogenic mimicry and immune microenvironment in breast cancer
摘要
Abstract
Objective To understand the relationship between the clinicopathological features of breast cancer and the expres-sion of vasculogenic mimicry(VM)and CD8+T cells.Futher to explore the correlation between VM and immune microenvironment.Methods 60 cases of breast cancer tissue samples were collected to make tissue chip.The expression of VM was detected by CD31/PAS double staining.IHC was used to assess the expression of CD8+T cells.The relationship among VM expression,CD8+T cell ex-pression and clinicopathological characteristics were analyzed,so as to infer the relationship between VM and CD8+T cells.Results Among 60 cases of breast cancer tissue samples,VM was detected in 24 cases(40％).The positive rate of VM in pathlogi-cal grade G3 was 63.2％,while it was 29.3％in tissues from G1 and G2.The difference was statistically significant(x2=6.213,P=0.013).The positive detection rate of VM in stage 111(54.5％)was significantly higher than that in stage Ⅰ/Ⅱ(x2=6.231,P=0.044).The positive expression of VM in triple negative type was significantly higher than that in other molecular types,and the difference was statistically significant(x2=14.0,P＜0.001).There was no significant difference in the detection rate of VM with age and histological types.The positive expression of CD8+T cells was detected in 26 cases(43.3％).The positive expression of CD8+T cells in triple negative breast cancer(TNBC)was significantly lower than that in other molecular subtypes,and the difference was sta-tistically significant(x2=7.454,P=0.006).There was no significant difference in the expression of CD8+T cells among age,histo-logical type,pathological grade and clinical stage.There was a significant difference in the expression of CD8+T cells between VM negative and positive in the whole samples(x2=11.584,P＜0.001),but there was no significant difference in TNBC samples(x2=1.313,P=0.252).Conclusion VM formation is more common in advanced and poorly differentiated breast cancer,especially in TN-BC,and CD8+T cells are more common in non-TNBC.In breast cancer with significant VM formation,CD8+T lymphocytes are often less.关键词
乳腺癌/血管生成拟态/肿瘤免疫微环境/CD8+T淋巴细胞Key words
breast cancer/vasculogenic mimicry/tumor im-mune microenvironment/CD8+T lymphocytes分类
医药卫生引用本文复制引用
黄竞,栾飞扬,马欣越,安亦扬,胡思睿,刘希,杨谨,董丹凤..乳腺癌血管生成拟态和免疫微环境关系的初步探索[J].武警医学,2025,36(1):16-20,5.基金项目
国家自然科学基金项目(82002803) （82002803）
陕西省重点研发计划(2020SF-029) （2020SF-029）
吴阶平医学基金项目(320.6750.2021-10-84) （320.6750.2021-10-84）
