武警医学2025，Vol.36Issue(1)：21-24,29,5.
胎盘植入性疾病患者血清PLGF、PAPP-A水平与植入深度及产后出血的关系
Relationship between serum PLGF,PAPP-A levels and implantation depth and postpar-tum hemorrhage in PAS patients
臧美春 1朱萍 1胡海云 1王元元 1林森2
作者信息
- 1. 266000 青岛,海军第971医院妇产科
- 2. 266000 青岛,海军第971医院普外科
- 折叠
摘要
Abstract
Objective To investigate the relationship between the levels of serum placental growth factor(PLGF),pregnan-cy-related plasma protein A(PAPP-A),implantation depth and postpartum hemorrhage in patients with placental implantable disease(PAS).Methods A total of 228 PAS patients(PAS group)admitted to No.971 Hospital of PLA Army from June 2018 to June 2023 were selected and divided into adhesion group(77 cases),implantation group(88 cases)and penetration group(63 cases)according to placental implantation depth,and 217 pregnant women with normal delivery during the same period were selected as control group.The levels of Serum PLGF and PAPP-A were detected,postpartum hemorrhage of PAS patients was analyzed,and the relationship be-tween PLGF,PAPP-A,PAS implantation depth and postpartum hemorrhage was analyzed.Results The levels of serum PLGF[(509.64±127.48)pg/ml vs.(356.12±101.24)pg/ml]and PAPP-A[(4 216.32±623.19)mU/L vs.(3213.54±305.43)mU/L]in PAS group were higher than those in control group(P＜0.05),and the levels of serum PLGF and PAPP-A in penetration group were higher than those in implant group and adhesion group(P＜0.05).High level of PLGF and high level of PAPP-A were risk factors for PAS postpartum hemorrhage(P＜0.05).The areas under the curve of PLGF and PAPP-A in predicting postpartum hemorrhage of PAS were 0.863 and 0.980,both of which had high value(P＜0.05).Conclusions The increase of serum PLGF and PAPP-A levels in PAS pregnant women is associated with the increase of placenta implantation depth and the risk of postpartum hemorrhage.The detec-tion of serum PLGF and PAPP-A levels is helpful to predict the postpartum hemorrhage in PAS.关键词
胎盘植入性疾病/胎盘植入/产后出血/胎盘生长因子/妊娠相关血浆蛋白AKey words
pernicious placenta previa/placenta accreta spectrum/postpartum hemorrhage/placental growth factor/pregnancy-associated plasma protein-A分类
医药卫生引用本文复制引用
臧美春,朱萍,胡海云,王元元,林森..胎盘植入性疾病患者血清PLGF、PAPP-A水平与植入深度及产后出血的关系[J].武警医学,2025,36(1):21-24,29,5.
