武警医学2025，Vol.36Issue(1)：30-33,4.
富马酸伏诺拉生治疗Hp阳性消化性溃疡的临床效果
Clinical effect of fumarate on Hp positive peptic ulcer
摘要
Abstract
Objective To investigate the clinical effect of fumarate in the treatment of Helicobacter pylori(Hp)positive pep-tic ulcer(PU).Methods A total of 94 HP-positive PU patients from the gastroenterology outpatient department of the Second Affilia-ted Hospital of Air Force Military Medical University from May 2022 to April 2024 were selected and randomly divided into control group and study group with 47 cases in each group.The control group was treated with amoxicillin+bismuth colloid pectin+clarithro-mycin+omeprazole,while the study group was treated with amoxicillin+bismuth colloid pectin+clarithromycin+fumarate Vonorazine orally for 2 weeks.The ulcer healing,Hp eradication,clinical efficacy,gastric acid secretion function and safety of the two groups were compared.Results The ulcer healing rate of the study group was 93.62％(44/47)higher than that of the control group(78.72％(37/47),and the difference was statistically significant(P＜0.05).Compared with the control group,the eradication rate of Hp in the study group was higher(87.23％vs.68.09％,P＜0.05).The total effective rate of the two groups was higher in the stud-y group(82.29％vs.95.74％,x2=7.029,P＜0.05).After treatment,basal gastric acid secretion(BAO),maximum gastric acid secretion(MAO)and peak gastric acid secretion(PAO)decreased in both groups.The BAO,MAO and PAO levels in the study group were(4.15±1.44)mmol/h,(8.02±2.13)mmol/h and(12.12±3.67)mmol/h lower than those in the control group(5.36±1.98)mmol/h,(10.15±2.99)mmol/h and(15.01±3.59)mmol/h(t=3.388,3.978,3.859,P＜0.05).There was no signifi-cant difference in the incidence of adverse reactions between the two groups(4.26％vs.10.64％,P＞0.05).Conclusions The treat-ment effect of fumarate on Hp positive PU is excellent,which is worthy of promotion due to the promotion of ulcer healing,inhibition of gastric acid secretion and its safety.关键词
消化性溃疡/幽门螺杆菌/富马酸伏诺拉生/胃酸分泌功能Key words
peptic ulcer/helicobacter pylori/Vonorazine fumarate/gastric acid secretion function分类
医药卫生引用本文复制引用
刘小刚,张娇娇,杨婷,刘成文..富马酸伏诺拉生治疗Hp阳性消化性溃疡的临床效果[J].武警医学,2025,36(1):30-33,4.基金项目
陕西省重点研发计划项目(2023-SF-32) （2023-SF-32）
