摘要
Abstract
Objective To study the clinical effect of dexmedetomidine and general anesthesia combined with inhalation in lap-aroscopic treatment of adults with indirect inguinal hernia in plateau.Methods A total of 97 patients who were treated with laparoscop-ic treatment of indirect inguinal hernia in Tibet Autonomous Regional Corps Hospital of Chinese People's Armed Police Force from De-cember 2020 to December 2022 were selected as subjects,and divided into observation group(n=48)and control group(n=49)by random number table method.The control group were given general anesthesia combined with inhalation,while the observation group were given dexmedetomidine and general anesthesia combined with inhalation.The general condition,anesthesia quality,hemodynam-ics,stress response,inflammatory factors and incidence of complications were compared between the two groups.Results The onset time of anesthesia[(6.37±1.24)min]and extubation time[(13.88±4.30)min]in the observation group were smaller than those in the control group[(9.12±3.45)min and(21.27±7.30)min;P＜0.05].The blood pressure during intoxication time in the observa-tion group[(126.30±12.45)/(76.38±6.80)mmHg]was higher than that in the control group[(120.15±10.37)/(71.44±4.93)mmHg].The heart rate[(73.41±10.07)times/min],mean arterial pressure[(86.39±14.07)mmHg]and heart index(2.38±0.77)in the observation group were lower than those in the control group[(79.60±11.53)times/min,(98.13±17.22)mmHg and(2.76±0.93).There was no significant difference in stress indexes and inflammatory factors between the two groups during anes-thesia induction period(P＞0.05).During anesthesia recovery period,the stress index cortisol,Ang Ⅱ and ALDO,inflammatory fac-tor IL-6,CRP and TNF-α,and complication rate in the observation group were lower than those in the control group(P＜0.05).Conclusions Dexmedetomidine and general anesthesia combined with inhalation can stabilize hemodynamics,reduce the levels of stress response and inflammatory factors,reduce the incidence of anesthesia complications and improve the safety of anesthesia in adult patients with indirect inguinal hernia in plateaus.关键词
右美托咪定/静吸复合全身麻醉/高原/腹股沟斜疝/腹腔镜手术Key words
dexmedetomidine/general anesthesia combined with inhalation/plateau/indirect inguinal hernia/laparoscope分类
医药卫生
